Regulation of Vasculogenesis by Platelet-Mediated Recruitment of Bone Marrow–Derived Cells

DOI Web Site 被引用文献2件
  • Daniel C. Rafii
    From the Departments of Pediatrics and Cell Biology (D.C.R., B.P., D.L.), and the Department of Genetic Medicine (J.B.D.K.J.), Weill Cornell Medical College and Memorial Sloan-Kettering Cancer Center, New York, NY.
  • Bethan Psaila
    From the Departments of Pediatrics and Cell Biology (D.C.R., B.P., D.L.), and the Department of Genetic Medicine (J.B.D.K.J.), Weill Cornell Medical College and Memorial Sloan-Kettering Cancer Center, New York, NY.
  • Jason Butler
    From the Departments of Pediatrics and Cell Biology (D.C.R., B.P., D.L.), and the Department of Genetic Medicine (J.B.D.K.J.), Weill Cornell Medical College and Memorial Sloan-Kettering Cancer Center, New York, NY.
  • David K. Jin
    From the Departments of Pediatrics and Cell Biology (D.C.R., B.P., D.L.), and the Department of Genetic Medicine (J.B.D.K.J.), Weill Cornell Medical College and Memorial Sloan-Kettering Cancer Center, New York, NY.
  • David Lyden
    From the Departments of Pediatrics and Cell Biology (D.C.R., B.P., D.L.), and the Department of Genetic Medicine (J.B.D.K.J.), Weill Cornell Medical College and Memorial Sloan-Kettering Cancer Center, New York, NY.

書誌事項

公開日
2008-02
DOI
  • 10.1161/atvbaha.107.151159
公開者
Ovid Technologies (Wolters Kluwer Health)

この論文をさがす

説明

<jats:p>Bone marrow–derived cells contribute to physiological and pathological vascular remodeling throughout ontogenesis and adult life. During tissue regeneration and tumor growth, the release of cytokines and chemokines mediates the recruitment of hematopoietic and endothelial progenitor cells that contribute to the assembly of neovessels. Current evidence implies that platelets contribute structurally and instructively to vascular remodeling. Platelets adhere almost immediately to exposed or activated endothelium, and they are major storage and delivery vehicles for pro- and antiangiogenic growth factors including VEGF-A and thrombospondin (TSP), and cytokines and chemokines, such as stromal-derived factor 1 (SDF-1). By site-specific deployment of these factors, platelets orchestrate the local angiogenic stimulus within a tissue and direct the recruitment and differentiation of circulating bone marrow–derived cells. These insights have profound clinical implications; inhibition of platelet-deployed growth factors or their receptors may be an effective strategy to block tumor growth, whereas activation of these pathways may be used to accelerate revascularization and tissue regeneration.</jats:p>

収録刊行物

被引用文献 (2)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ