The gut microbiome in human neurological disease: A review

DOI Web Site Web Site 被引用文献8件
  • Helen Tremlett
    Faculty of Medicine (Neurology) and the Djavad Mowafaghian Centre for Brain Health University of British Columbia Vancouver British Columbia Canada
  • Kylynda C. Bauer
    Microbiology and Immunology, Michael Smith Laboratories University of British Columbia Vancouver British Columbia Canada
  • Silke Appel‐Cresswell
    Faculty of Medicine (Neurology) and the Djavad Mowafaghian Centre for Brain Health University of British Columbia Vancouver British Columbia Canada
  • Brett B. Finlay
    Microbiology and Immunology, Michael Smith Laboratories University of British Columbia Vancouver British Columbia Canada
  • Emmanuelle Waubant
    University of California San Francisco San Francisco CA

書誌事項

公開日
2017-03
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1002/ana.24901
公開者
Wiley

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説明

<jats:p>Almost half the cells and 1% of the unique genes found in our bodies are human, the rest are from microbes, predominantly bacteria, archaea, fungi, and viruses. These microorganisms collectively form the human microbiota, with most colonizing the gut. Recent technological advances, open access data libraries, and application of high‐throughput sequencing have allowed these microbes to be identified and their contribution to neurological health to be examined. Emerging evidence links perturbations in the gut microbiota to neurological disease, including disease risk, activity, and progression. This review provides an overview of the recent advances in microbiome research in relation to neuro(auto)immune and neurodegenerative conditions affecting humans, such as multiple sclerosis, neuromyelitis optica spectrum disorders, Parkinson disease, Alzheimer disease, Huntington disease, and amyotrophic lateral sclerosis. Study design and terminology used in this rapidly evolving, highly multidisciplinary field are summarized to empower and engage the neurology community in this “newly discovered organ.” Ann Neurol 2017;81:369–382</jats:p>

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