Stimulation of Bone Formation in Vitro and in Rodents by Statins

DOI Web Site 122 Citations
  • G. Mundy
    OsteoScreen, 2040 Babcock Road, San Antonio, TX 78229, USA.
  • R. Garrett
    OsteoScreen, 2040 Babcock Road, San Antonio, TX 78229, USA.
  • S. Harris
    Department of Medicine,
  • J. Chan
    OsteoScreen, 2040 Babcock Road, San Antonio, TX 78229, USA.
  • D. Chen
    OsteoScreen, 2040 Babcock Road, San Antonio, TX 78229, USA.
  • G. Rossini
    OsteoScreen, 2040 Babcock Road, San Antonio, TX 78229, USA.
  • B. Boyce
    Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284–7877, USA.
  • M. Zhao
    OsteoScreen, 2040 Babcock Road, San Antonio, TX 78229, USA.
  • G. Gutierrez
    OsteoScreen, 2040 Babcock Road, San Antonio, TX 78229, USA.

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Description

<jats:p> Osteoporosis and other diseases of bone loss are a major public health problem. Here it is shown that the statins, drugs widely used for lowering serum cholesterol, also enhance new bone formation in vitro and in rodents. This effect was associated with increased expression of the bone morphogenetic protein–2 ( <jats:italic>BMP-2</jats:italic> ) gene in bone cells. Lovastatin and simvastatin increased bone formation when injected subcutaneously over the calvaria of mice and increased cancellous bone volume when orally administered to rats. Thus, in appropriate doses, statins may have therapeutic applications for the treatment of osteoporosis. </jats:p>

Journal

  • Science

    Science 286 (5446), 1946-1949, 1999-12-03

    American Association for the Advancement of Science (AAAS)

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