Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes

DOI Web Site 18 Citations
  • Onur Boyman
    Department of Immunology, IMM4, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • Marek Kovar
    Department of Immunology, IMM4, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • Mark P. Rubinstein
    Department of Immunology, IMM4, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • Charles D. Surh
    Department of Immunology, IMM4, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • Jonathan Sprent
    Department of Immunology, IMM4, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Description

<jats:p> Interleukin-2 (IL-2), which is a growth factor for T lymphocytes, can also sometimes be inhibitory. Thus, the proliferation of CD8 <jats:sup>+</jats:sup> T cells in vivo is increased after the injection of a monoclonal antibody that is specific for IL-2 (IL-2 mAb), perhaps reflecting the removal of IL-2–dependent CD4 <jats:sup>+</jats:sup> T regulatory cells (T regs). Instead, we show here that IL-2 mAb augments the proliferation of CD8 <jats:sup>+</jats:sup> cells in mice simply by increasing the biological activity of preexisting IL-2 through the formation of immune complexes. When coupled with recombinant IL-2, some IL-2/IL-2 mAb complexes cause massive (>100-fold) expansion of CD8 <jats:sup>+</jats:sup> cells in vivo, whereas others selectively stimulate CD4 <jats:sup>+</jats:sup> T regs. Thus, different cytokine-antibody complexes can be used to selectively boost or inhibit the immune response. </jats:p>

Journal

  • Science

    Science 311 (5769), 1924-1927, 2006-03-31

    American Association for the Advancement of Science (AAAS)

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