Emergence of Antimicrobial Resistance among Pseudomonas aeruginosa: Implications for Therapy
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- George Zhanel
- Department of Medical Microbiology/Infectious Diseases, Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
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- Nina Clark
- Division of Infectious Diseases, Department of Medicine, Loyola University Medical Center, Maywood, Illinois
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- Joseph Lynch
- Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California
抄録
<jats:title>Abstract</jats:title><jats:p> Pseudomonas aeruginosa (PA), a nonlactose fermenting gram-negative bacillus, is a common cause of nosocomial infections in critically ill or debilitated patients, particularly ventilator-associated pneumonia (VAP), and infections of bloodstream, urinary tract, intra-abdominal, wounds/skin/soft tissue. PA rarely affects healthy individuals, but may cause serious infections in patients with chronic structural lung disease, comorbidities, advanced age, impaired immune defenses, or with medical devices (e.g., urinary or intravascular catheters, foreign bodies). Treatment of pseudomonal infections is difficult, as PA is intrinsically resistant to multiple antimicrobials, and may acquire new resistance determinants even while on antimicrobial therapy. Mortality associated with pseudomonal VAP or bacteremias is high (> 35%) and optimal therapy is controversial. Over the past three decades, antimicrobial resistance among PA has escalated globally, via dissemination of several international multidrug-resistant “epidemic” clones. We review the emergence of antimicrobial resistance to this pathogen, and discuss approaches to therapy (both empirical and definitive).</jats:p>
収録刊行物
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- Seminars in Respiratory and Critical Care Medicine
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Seminars in Respiratory and Critical Care Medicine 38 (03), 326-345, 2017-06
Georg Thieme Verlag KG