Guidelines for measuring cardiac physiology in mice

DOI Web Site 6 Citations
  • Merry L. Lindsey
    Department of Physiology and Biophysics, Mississippi Center for Heart Research, University of Mississippi Medical Center, Jackson, Mississippi
  • Zamaneh Kassiri
    Department of Physiology, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
  • Jitka A. I. Virag
    Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, North Carolina
  • Lisandra E. de Castro Brás
    Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, North Carolina
  • Marielle Scherrer-Crosbie
    Cardiac Ultrasound Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania

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<jats:p>Cardiovascular disease is a leading cause of death, and translational research is needed to understand better mechanisms whereby the left ventricle responds to injury. Mouse models of heart disease have provided valuable insights into mechanisms that occur during cardiac aging and in response to a variety of pathologies. The assessment of cardiovascular physiological responses to injury or insult is an important and necessary component of this research. With increasing consideration for rigor and reproducibility, the goal of this guidelines review is to provide best-practice information regarding how to measure accurately cardiac physiology in animal models. In this article, we define guidelines for the measurement of cardiac physiology in mice, as the most commonly used animal model in cardiovascular research.</jats:p><jats:p>Listen to this article’s corresponding podcast at http://ajpheart.podbean.com/e/guidelines-for-measuring-cardiac-physiology-in-mice/ .</jats:p>

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