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- Jozef Dulak
- From the Department of Medicine, Nephrology Research and Training Center, Center for Free Radical Biology, Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham (J. Deshane, A.A.); and Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland (J. Dulak, A.J.).
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- Jessy Deshane
- From the Department of Medicine, Nephrology Research and Training Center, Center for Free Radical Biology, Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham (J. Deshane, A.A.); and Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland (J. Dulak, A.J.).
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- Alicja Jozkowicz
- From the Department of Medicine, Nephrology Research and Training Center, Center for Free Radical Biology, Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham (J. Deshane, A.A.); and Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland (J. Dulak, A.J.).
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- Anupam Agarwal
- From the Department of Medicine, Nephrology Research and Training Center, Center for Free Radical Biology, Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham (J. Deshane, A.A.); and Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland (J. Dulak, A.J.).
書誌事項
- タイトル別名
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- Focus on Angiogenesis
説明
<jats:p>Angiogenesis involves the formation of new blood vessels and is critical for fundamental events such as development and repair after injury. Perturbances in angiogenesis contribute to the pathogenesis of diverse clinical conditions including cancer, complications of diabetes mellitus, ischemia/reperfusion injury of the heart and other organs, and preeclampsia, as well as a number of inflammatory disorders. Recent work has identified heme oxygenase-1 and its gaseous product, carbon monoxide, to possess potent proangiogenic properties in addition to well-recognized antiinflammatory, antioxidant, and antiapoptotic effects. Angiogenic factors, such as vascular endothelial growth factor and stromal cell–derived factor-1, mediate their proangiogenic effects through induction of heme oxygenase-1, making it an attractive target for therapeutic intervention. This review will provide an overview of the role of heme oxygenase-1 and carbon monoxide in angiogenesis.</jats:p>
収録刊行物
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- Circulation
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Circulation 117 (2), 231-241, 2008-01-15
Ovid Technologies (Wolters Kluwer Health)