Somatostatin-positive interneurons in the dentate gyrus of mice provide local- and long-range septal synaptic inhibition

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  • Mei Yuan
    Systemic and Cellular Neurophysiology, Institute for Physiology I, University of Freiburg, Freiburg, Germany
  • Thomas Meyer
    Systemic and Cellular Neurophysiology, Institute for Physiology I, University of Freiburg, Freiburg, Germany
  • Christoph Benkowitz
    Systemic and Cellular Neurophysiology, Institute for Physiology I, University of Freiburg, Freiburg, Germany
  • Shakuntala Savanthrapadian
    Systemic and Cellular Neurophysiology, Institute for Physiology I, University of Freiburg, Freiburg, Germany
  • Laura Ansel-Bollepalli
    Institute for Physiology, University of Kiel, Kiel, Germany
  • Angelica Foggetti
    Institute for Physiology, University of Kiel, Kiel, Germany
  • Peer Wulff
    Institute for Physiology, University of Kiel, Kiel, Germany
  • Pepe Alcami
    Systemic and Cellular Neurophysiology, Institute for Physiology I, University of Freiburg, Freiburg, Germany
  • Claudio Elgueta
    Systemic and Cellular Neurophysiology, Institute for Physiology I, University of Freiburg, Freiburg, Germany
  • Marlene Bartos
    Systemic and Cellular Neurophysiology, Institute for Physiology I, University of Freiburg, Freiburg, Germany

Abstract

<jats:p>Somatostatin-expressing-interneurons (SOMIs) in the dentate gyrus (DG) control formation of granule cell (GC) assemblies during memory acquisition. Hilar-perforant-path-associated interneurons (HIPP cells) have been considered to be synonymous for DG-SOMIs. Deviating from this assumption, we show two functionally contrasting DG-SOMI-types. The classical feedback-inhibitory HIPPs distribute axon fibers in the molecular layer. They are engaged by converging GC-inputs and provide dendritic inhibition to the DG circuitry. In contrast, SOMIs with axon in the hilus, termed hilar interneurons (HILs), provide perisomatic inhibition onto GABAergic cells in the DG and project to the medial septum. Repetitive activation of glutamatergic inputs onto HIPP cells induces long-lasting-depression (LTD) of synaptic transmission but long-term-potentiation (LTP) of synaptic signals in HIL cells. Thus, LTD in HIPPs may assist flow of spatial information from the entorhinal cortex to the DG, whereas LTP in HILs may facilitate the temporal coordination of GCs with activity patterns governed by the medial septum.</jats:p>

Journal

  • eLife

    eLife 6 e21105-, 2017-04-03

    eLife Sciences Publications, Ltd

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