A prenatal nicotine exposure mouse model of methylphenidate responsive ADHD‐associated cognitive phenotypes

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  • Jinmin Zhu
    Center for Brain Repair and The Department of Biomedical Sciences Florida State University College of Medicine Tallahassee FL 32306 United States
  • Fangfang Fan
    Center for Brain Repair and The Department of Biomedical Sciences Florida State University College of Medicine Tallahassee FL 32306 United States
  • Deirdre M. McCarthy
    Center for Brain Repair and The Department of Biomedical Sciences Florida State University College of Medicine Tallahassee FL 32306 United States
  • Lin Zhang
    Center for Brain Repair and The Department of Biomedical Sciences Florida State University College of Medicine Tallahassee FL 32306 United States
  • Elisa N. Cannon
    Center for Brain Repair and The Department of Biomedical Sciences Florida State University College of Medicine Tallahassee FL 32306 United States
  • Thomas J. Spencer
    Pediatric Psychopharmacology, Department of Psychiatry Massachusetts General Hospital, Harvard Medical School Boston MA 02114 United States
  • Joseph Biederman
    Pediatric Psychopharmacology, Department of Psychiatry Massachusetts General Hospital, Harvard Medical School Boston MA 02114 United States
  • Pradeep G. Bhide
    Center for Brain Repair and The Department of Biomedical Sciences Florida State University College of Medicine Tallahassee FL 32306 United States

書誌事項

公開日
2017-02-04
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1016/j.ijdevneu.2017.01.014
公開者
Wiley

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<jats:title>Abstract</jats:title><jats:p>Prenatal exposure to nicotine via cigarette smoke or other forms of tobacco use is a significant environmental risk factor for attention deficit hyperactivity disorder (ADHD). The neurobiological mechanisms underlying the link between prenatal nicotine exposure (PNE) and ADHD are not well understood. Animal models, especially rodent models, are beginning to bridge this gap in knowledge. Although ADHD is characterized by hyperactivity, inattention, impulsivity and working memory deficits, the majority of the animal models are based on only one or two ADHD associated phenotypes, in particular, hyperactivity or inattention. We report a PNE mouse model that displays the full range of ADHD associated behavioral phenotypes including working memory deficit, attention deficit and impulsive‐like behavior. All of the ADHD‐associated phenotypes respond to a single administration of a therapeutic equivalent dose of methylphenidate. In an earlier study, we showed that PNE produces hyperactivity, frontal cortical hypodopaminergic state and thinning of the cingulate cortex. Collectively, these data suggest that the PNE mouse model recapitulates key features of ADHD and may be a suitable preclinical model for ADHD research.</jats:p>

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