4‐Aryldihydropyridines, a New Class of Highly Active Calcium Antagonists

Friedrich Bossert, Horst Meyer, Egbert Wehinger

doi:10.1002/anie.198107621

4‐Aryldihydropyridines, a New Class of Highly Active Calcium Antagonists

DOI Web Site Web Site 被引用文献4件

書誌事項

公開日: 1981-09

権利情報

http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1002/anie.198107621

公開者: Wiley

この論文をさがす

CiNii Books

説明

<jats:title>Abstract</jats:title><jats:p>The aryldihydropyridines first prepared by <jats:italic>Hantzsch</jats:italic> almost 100 years ago have recently been found to be highly effective calcium antagonists with suitable pharmacological profiles. An illustrative example is dimethyl‐l,4‐dihydro‐2,6‐dimethyl‐4‐(<jats:italic>o</jats:italic>‐nitrophenyl)pyridine‐3,5‐dicarboxylate (Nifedipine) which is already employed therapeutically. This substance lowers the frequency of attack of angina pectoris and reduces blood pressure. The discovery of the therapeutic activity of this class of substances initiated renewed investigation of the Hantzsch condensation and the synthesis of numerous 4‐aryldihydropyridines and related compounds. Qualitative and quantitative structure/activity relationships of these substances can be deduced from their biological data.</jats:p>