Iminosugar Glycosidase Inhibitors:  Structural and Thermodynamic Dissection of the Binding of Isofagomine and 1-Deoxynojirimycin to β-Glucosidases

  • David L. Zechel
    Contribution from the Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, YO10 5YW, United Kingdom, and School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley WA 6009, Australia
  • Alisdair B. Boraston
    Contribution from the Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, YO10 5YW, United Kingdom, and School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley WA 6009, Australia
  • Tracey Gloster
    Contribution from the Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, YO10 5YW, United Kingdom, and School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley WA 6009, Australia
  • Catherine M. Boraston
    Contribution from the Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, YO10 5YW, United Kingdom, and School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley WA 6009, Australia
  • James M. Macdonald
    Contribution from the Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, YO10 5YW, United Kingdom, and School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley WA 6009, Australia
  • D. Matthew G. Tilbrook
    Contribution from the Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, YO10 5YW, United Kingdom, and School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley WA 6009, Australia
  • Robert V. Stick
    Contribution from the Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, YO10 5YW, United Kingdom, and School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley WA 6009, Australia
  • Gideon J. Davies
    Contribution from the Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, YO10 5YW, United Kingdom, and School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley WA 6009, Australia

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