Association of Anthropometric Characteristics with the Risk of Malignant Lymphoma and Plasma Cell Myeloma in a Japanese Population: A Population-Based Cohort Study
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- Junya Kanda
- Authors' Affiliations: 1Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute; 2Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; 3Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; and 4Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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- Keitaro Matsuo
- Authors' Affiliations: 1Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute; 2Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; 3Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; and 4Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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- Manami Inoue
- Authors' Affiliations: 1Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute; 2Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; 3Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; and 4Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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- Motoki Iwasaki
- Authors' Affiliations: 1Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute; 2Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; 3Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; and 4Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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- Norie Sawada
- Authors' Affiliations: 1Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute; 2Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; 3Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; and 4Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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- Taichi Shimazu
- Authors' Affiliations: 1Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute; 2Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; 3Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; and 4Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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- Taiki Yamaji
- Authors' Affiliations: 1Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute; 2Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; 3Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; and 4Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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- Shizuka Sasazuki
- Authors' Affiliations: 1Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute; 2Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; 3Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; and 4Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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- Shoichiro Tsugane
- Authors' Affiliations: 1Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute; 2Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; 3Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; and 4Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
説明
<jats:title>Abstract</jats:title><jats:p>Background: Although Asian and Western populations differ markedly in anthropometric characteristics and the incidence of malignant lymphoma and plasma cell myeloma, few studies have evaluated the associations between these variables among Asian populations.</jats:p><jats:p>Methods: We conducted a large-scale, population-based prospective study in a Japanese cohort that included 45,007 men and 49,540 women ages 40 to 69 years at baseline. During an average follow-up period of 13 years, 257 cases of malignant lymphoma and 88 of plasma cell myeloma were identified. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated with the use of a Cox regression model adjusted for potential confounders.</jats:p><jats:p>Results: Compared with the 1st quartile, categorization in the 4th quartile for height showed a positive association with lymphoid neoplasm risk (HR, 1.38; 95% CI, 1.00-1.91), and the association was significant among men (HR, 1.72; 95% CI, 1.11-2.66). A similar trend was observed for subcategories of malignant lymphoma, plasma cell myeloma, and non–Hodgkin lymphoma, albeit the associations were weak due to the small number of subjects in each category. In contrast, weight and body mass index were not associated with risk of lymphoid neoplasm.</jats:p><jats:p>Conclusions: Height was positively associated with risk of lymphoid neoplasm in a Japanese population.</jats:p><jats:p>Impact: Our data suggested that early life exposure to growth-related hormones, such as insulin-like growth factors and growth hormones, or genetic factors relating to height may affect the risk of lymphoid neoplasm. Cancer Epidemiol Biomarkers Prev; 19(6); 1623–31. ©2010 AACR.</jats:p>
収録刊行物
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- Cancer Epidemiology, Biomarkers & Prevention
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Cancer Epidemiology, Biomarkers & Prevention 19 (6), 1623-1631, 2010-06-01
American Association for Cancer Research (AACR)