A Versatile Toolkit to Produce Sensitive FRET Biosensors to Visualize Signaling in Time and Space

DOI Web Site 7 Citations
  • Rafael D. Fritz
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
  • Michel Letzelter
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
  • Andreas Reimann
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
  • Katrin Martin
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
  • Ludovico Fusco
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
  • Laila Ritsma
    Hubrecht Institute–Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.
  • Bas Ponsioen
    Hubrecht Institute–Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.
  • Erika Fluri
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
  • Stefan Schulte-Merker
    Hubrecht Institute–Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.
  • Jacco van Rheenen
    Hubrecht Institute–Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.
  • Olivier Pertz
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.

Description

<jats:p>Next-generation biosensors enable in vivo monitoring of ERK activity and detection of RhoA activity in small cellular extensions.</jats:p>

Journal

  • Science Signaling

    Science Signaling 6 (285), rs12-, 2013-07-23

    American Association for the Advancement of Science (AAAS)

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