Genome-Wide Reprogramming in the Mouse Germ Line Entails the Base Excision Repair Pathway
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- Petra Hajkova
- Wellcome Trust–Cancer Research U.K. Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.
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- Sean J. Jeffries
- Wellcome Trust–Cancer Research U.K. Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.
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- Caroline Lee
- Wellcome Trust–Cancer Research U.K. Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.
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- Nigel Miller
- Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.
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- Stephen P. Jackson
- Wellcome Trust–Cancer Research U.K. Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.
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- M. Azim Surani
- Wellcome Trust–Cancer Research U.K. Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.
説明
<jats:title>Erasing Markers</jats:title> <jats:p> Epigenetic reprogramming of the mammalian genome, which involves the removal and replacement of the various regulatory epigenetic marks such as DNA methylation, occurs during germ cell differentiation and during early zygotic development. This process is also critical during the experimental generation of stem cells, but the factors and pathways that control epigenetic reprogramming are not well understood. <jats:bold> Hajkova <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="78" related-article-type="in-this-issue" vol="329" xlink:href="10.1126/science.1187945">78</jats:related-article> ) investigated the erasure of DNA methylation during germ cell differentiation and during early zygotic development in the developing mouse and found that factors involved in the base excision repair (BER) pathway, which helps repair damaged DNA, were involved. Furthermore, inhibitors of BER resulted in the retention of DNA methylation in the zygote. </jats:p>
収録刊行物
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- Science
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Science 329 (5987), 78-82, 2010-07-02
American Association for the Advancement of Science (AAAS)
