The influence of iron deficiency on the functioning of skeletal muscles: experimental evidence and clinical implications

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  • Magdalena Stugiewicz
    Students' Scientific Association, Laboratory for Applied Research on Cardiovascular System, Department of Heart Diseases Wroclaw Medical University Wroclaw Poland
  • Michał Tkaczyszyn
    Laboratory for Applied Research on Cardiovascular System, Department of Heart Diseases Wroclaw Medical University Wroclaw Poland
  • Monika Kasztura
    Laboratory for Applied Research on Cardiovascular System, Department of Heart Diseases Wroclaw Medical University Wroclaw Poland
  • Waldemar Banasiak
    Cardiology Department, Centre for Heart Diseases Military Hospital Wroclaw Poland
  • Piotr Ponikowski
    Cardiology Department, Centre for Heart Diseases Military Hospital Wroclaw Poland
  • Ewa A. Jankowska
    Laboratory for Applied Research on Cardiovascular System, Department of Heart Diseases Wroclaw Medical University Wroclaw Poland

説明

<jats:p>Skeletal and respiratory myopathy not only constitutes an important pathophysiological feature of heart failure and chronic obstructive pulmonary disease, but also contributes to debilitating symptomatology and predicts worse outcomes in these patients. Accumulated evidence from laboratory experiments, animal models, and interventional studies in sports medicine suggests that undisturbed systemic iron homeostasis significantly contributes to the effective functioning of skeletal muscles. In this review, we discuss the role of iron status for the functioning of skeletal muscle tissue, and highlight iron deficiency as an emerging therapeutic target in chronic diseases accompanied by a marked muscle dysfunction.</jats:p>

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