Amelanotic Melanoma Masquerading as a Granular Cell Lesion

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  • Deepak Pandiar
    Department of Oral and Maxillofacial Pathology, Government Dental College, Kozhikode, Kerala 673008, India
  • Shaini Basheer
    Department of Oral and Maxillofacial Pathology, Government Dental College, Kozhikode, Kerala 673008, India
  • P. M. Shameena
    Department of Oral and Maxillofacial Pathology, Government Dental College, Kozhikode, Kerala 673008, India
  • S. Sudha
    Department of Oral and Maxillofacial Pathology, Government Dental College, Kozhikode, Kerala 673008, India
  • Lakshmi J. Dhana
    Department of Oral and Maxillofacial Pathology, Government Dental College, Kozhikode, Kerala 673008, India

Description

<jats:p>Amelanotic melanoma (AM) presents a diagnostic challenge due to its wide clinical presentations, lack of pigmentation, and varied histological appearances. Immunohistochemistry plays a crucial role in the diagnosis of these lesions. Amelanotic melanoma of oral mucosa is an uncommon lesion. We report a case of a 50-year-old male patient with a growth on the anterior mandibular gingiva of seven-month duration. In the present case, histologically, the tumour resembled a granular cell lesion, which has not been reported previously in AM. Diagnosis was possible by a sequential panel of immunohistochemical markers, of which finally vimentin, S100, HMB45, and Melan-A were positive. The tumor was surgically excised, and postsurgical radiotherapy was given.</jats:p>

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