Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

  • Arun C. Habermann
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Austin J. Gutierrez
    Translational Genomics Research Institute, Phoenix, AZ, USA.
  • Linh T. Bui
    Translational Genomics Research Institute, Phoenix, AZ, USA.
  • Stephanie L. Yahn
    Translational Genomics Research Institute, Phoenix, AZ, USA.
  • Nichelle I. Winters
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Carla L. Calvi
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Lance Peter
    Translational Genomics Research Institute, Phoenix, AZ, USA.
  • Mei-I Chung
    Translational Genomics Research Institute, Phoenix, AZ, USA.
  • Chase J. Taylor
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Christopher Jetter
    Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Latha Raju
    Vanderbilt Center for Advanced Genomics, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Jamie Roberson
    Vanderbilt Center for Advanced Genomics, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Guixiao Ding
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Lori Wood
    Department of Thoracic Disease and Transplantation, Norton Thoracic Institute, Phoenix, AZ, USA.
  • Jennifer M. S. Sucre
    Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Bradley W. Richmond
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Ana P. Serezani
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Wyatt J. McDonnell
    Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Simon B. Mallal
    Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Matthew J. Bacchetta
    Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
  • James E. Loyd
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Ciara M. Shaver
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Lorraine B. Ware
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Ross Bremner
    Department of Thoracic Disease and Transplantation, Norton Thoracic Institute, Phoenix, AZ, USA.
  • Rajat Walia
    Department of Thoracic Disease and Transplantation, Norton Thoracic Institute, Phoenix, AZ, USA.
  • Timothy S. Blackwell
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Nicholas E. Banovich
    Translational Genomics Research Institute, Phoenix, AZ, USA.
  • Jonathan A. Kropski
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

説明

<jats:p>Single-cell RNA sequencing provides new insights into pathologic epithelial and mesenchymal remodeling in the human lung.</jats:p>

収録刊行物

  • Science Advances

    Science Advances 6 (28), eaba1972-, 2020-07-10

    American Association for the Advancement of Science (AAAS)

被引用文献 (9)*注記

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