Serum high‐molecular weight adiponectin is related to early postprandial glycemic increases and gastric emptying in patients with type 2 diabetes mellitus

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Postprandial hyperglycemia and hyperlipidemia are frequently associated with type 2 diabetes mellitus. The aim of the present study is to investigate the clinical determinants of postprandial glycemia and lipemia, especially serum high‐molecular weight adiponectin.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Twenty‐seven diabetic patients treated with diet alone and 13 healthy volunteers took liquid test meal containing 53 g carbohydrate and 47 g lipid, dosed with nonradioactive isotope <jats:sup>13</jats:sup>C‐acetate. Venous blood and breath samples were obtained for 180 min after the meal. Gastric emptying was evaluated by peak excretion time of <jats:sup>13</jats:sup>CO<jats:sub>2</jats:sub> in the breath samples. Delayed gastric emptying was defined as peak excretion time > 2.5 h (mean + 2 SD in the healthy volunteers).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Diabetic patients showed delayed insulin secretion, postprandial hyperglycemia and hyperlipidemia compared with control. Postprandial glycemic increases significantly correlated with enhanced gastric emptying. Serum high‐molecular weight adiponectin correlated with postprandial glycemic increases at 30 and 60 min after meal (<jats:italic>r</jats:italic> = 0.42, <jats:italic>p</jats:italic> < 0.05; <jats:italic>r</jats:italic> = 0.37, <jats:italic>p</jats:italic> < 0.05, respectively). Serum high‐molecular weight adiponectin also correlated with gastric emptying (<jats:italic>versus</jats:italic> peak excretion time <jats:italic>r</jats:italic> = − 0.58, <jats:italic>p</jats:italic> < 0.05). In addition, diabetic patients with delayed gastric emptying showed the suppressed postprandial glycemia with lower serum high‐molecular weight adiponectin than those with normal gastric emptying. On the other hand, postprandial increases in serum triglyceride were not related to serum high‐molecular weight adiponectin or gastric emptying, but significantly related to liver function test (serum transaminases) and body mass index.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Early postprandial glycemic increases were related to elevated serum high‐molecular weight adiponectin, which might be associated with enhanced gastric emptying. Copyright © 2009 John Wiley & Sons, Ltd.</jats:p></jats:sec>