Guidelines for experimental models of myocardial ischemia and infarction

DOI Web Site 被引用文献4件
  • Merry L. Lindsey
    Mississippi Center for Heart Research, Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi
  • Roberto Bolli
    Division of Cardiovascular Medicine and Institute of Molecular Cardiology, University of Louisville, Louisville, Kentucky
  • John M. Canty
    Division of Cardiovascular Medicine, Departments of Biomedical Engineering and Physiology and Biophysics, The Veterans Affairs Western New York Health Care System and Clinical and Translational Science Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York
  • Xiao-Jun Du
    Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia
  • Nikolaos G. Frangogiannis
    The Wilf Family Cardiovascular Research Institute, Department of Medicine (Cardiology), Albert Einstein College of Medicine, Bronx, New York
  • Stefan Frantz
    Department of Internal Medicine I, University Hospital, Würzburg, Germany
  • Robert G. Gourdie
    Center for Heart and Regenerative Medicine Research, Virginia Tech Carilion Research Institute, Roanoke, Virginia
  • Jeffrey W. Holmes
    Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, Virginia
  • Steven P. Jones
    Department of Medicine, Institute of Molecular Cardiology, Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky
  • Robert A. Kloner
    HMRI Cardiovascular Research Institute, Huntington Medical Research Institutes, Pasadena, California
  • David J. Lefer
    Cardiovascular Center of Excellence, Louisiana State University Health Science Center, New Orleans, Louisiana
  • Ronglih Liao
    Harvard Medical School, Boston, Massachusetts
  • Elizabeth Murphy
    Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
  • Peipei Ping
    National Institutes of Health BD2KBig Data to Knowledge (BD2K) Center of Excellence and Department of Physiology, Medicine and Bioinformatics, University of California, Los Angeles, California
  • Karin Przyklenk
    Cardiovascular Research Institute and Departments of Physiology and Emergency Medicine, Wayne State University School of Medicine, Detroit, Michigan
  • Fabio A. Recchia
    Institute of Life Sciences, Scuola Superiore Sant'Anna, Fondazione G. Monasterio, Pisa, Italy
  • Lisa Schwartz Longacre
    Heart Failure and Arrhythmias Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
  • Crystal M. Ripplinger
    Department of Pharmacology, School of Medicine, University of California, Davis, California
  • Jennifer E. Van Eyk
    The Smidt Heart Institute, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California
  • Gerd Heusch
    Institute for Pathophysiology, West German Heart and Vascular Center, University of Essen Medical School, Essen, Germany

抄録

<jats:p>Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial ischemia with or without reperfusion, and basic and translational research is needed to better understand its underlying mechanisms and consequences for cardiac structure and function. Ischemia underlies a broad range of clinical scenarios ranging from angina to hibernation to permanent occlusion, and while reperfusion is mandatory for salvage from ischemic injury, reperfusion also inflicts injury on its own. In this consensus statement, we present recommendations for animal models of myocardial ischemia and infarction. With increasing awareness of the need for rigor and reproducibility in designing and performing scientific research to ensure validation of results, the goal of this review is to provide best practice information regarding myocardial ischemia-reperfusion and infarction models.</jats:p><jats:p>Listen to this article’s corresponding podcast at ajpheart.podbean.com/e/guidelines-for-experimental-models-of-myocardial-ischemia-and-infarction/.</jats:p>

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