-
- Merry L. Lindsey
- Mississippi Center for Heart Research, Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi
-
- Roberto Bolli
- Division of Cardiovascular Medicine and Institute of Molecular Cardiology, University of Louisville, Louisville, Kentucky
-
- John M. Canty
- Division of Cardiovascular Medicine, Departments of Biomedical Engineering and Physiology and Biophysics, The Veterans Affairs Western New York Health Care System and Clinical and Translational Science Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York
-
- Xiao-Jun Du
- Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia
-
- Nikolaos G. Frangogiannis
- The Wilf Family Cardiovascular Research Institute, Department of Medicine (Cardiology), Albert Einstein College of Medicine, Bronx, New York
-
- Stefan Frantz
- Department of Internal Medicine I, University Hospital, Würzburg, Germany
-
- Robert G. Gourdie
- Center for Heart and Regenerative Medicine Research, Virginia Tech Carilion Research Institute, Roanoke, Virginia
-
- Jeffrey W. Holmes
- Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, Virginia
-
- Steven P. Jones
- Department of Medicine, Institute of Molecular Cardiology, Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky
-
- Robert A. Kloner
- HMRI Cardiovascular Research Institute, Huntington Medical Research Institutes, Pasadena, California
-
- David J. Lefer
- Cardiovascular Center of Excellence, Louisiana State University Health Science Center, New Orleans, Louisiana
-
- Ronglih Liao
- Harvard Medical School, Boston, Massachusetts
-
- Elizabeth Murphy
- Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
-
- Peipei Ping
- National Institutes of Health BD2KBig Data to Knowledge (BD2K) Center of Excellence and Department of Physiology, Medicine and Bioinformatics, University of California, Los Angeles, California
-
- Karin Przyklenk
- Cardiovascular Research Institute and Departments of Physiology and Emergency Medicine, Wayne State University School of Medicine, Detroit, Michigan
-
- Fabio A. Recchia
- Institute of Life Sciences, Scuola Superiore Sant'Anna, Fondazione G. Monasterio, Pisa, Italy
-
- Lisa Schwartz Longacre
- Heart Failure and Arrhythmias Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
-
- Crystal M. Ripplinger
- Department of Pharmacology, School of Medicine, University of California, Davis, California
-
- Jennifer E. Van Eyk
- The Smidt Heart Institute, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California
-
- Gerd Heusch
- Institute for Pathophysiology, West German Heart and Vascular Center, University of Essen Medical School, Essen, Germany
説明
<jats:p>Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial ischemia with or without reperfusion, and basic and translational research is needed to better understand its underlying mechanisms and consequences for cardiac structure and function. Ischemia underlies a broad range of clinical scenarios ranging from angina to hibernation to permanent occlusion, and while reperfusion is mandatory for salvage from ischemic injury, reperfusion also inflicts injury on its own. In this consensus statement, we present recommendations for animal models of myocardial ischemia and infarction. With increasing awareness of the need for rigor and reproducibility in designing and performing scientific research to ensure validation of results, the goal of this review is to provide best practice information regarding myocardial ischemia-reperfusion and infarction models.</jats:p><jats:p>Listen to this article’s corresponding podcast at ajpheart.podbean.com/e/guidelines-for-experimental-models-of-myocardial-ischemia-and-infarction/.</jats:p>
収録刊行物
-
- American Journal of Physiology-Heart and Circulatory Physiology
-
American Journal of Physiology-Heart and Circulatory Physiology 314 (4), H812-H838, 2018-04-01
American Physiological Society