Calorie restriction in humans inhibits the <scp>PI</scp>3<scp>K</scp>/<scp>AKT</scp> pathway and induces a younger transcription profile
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- Evi M. Mercken
- Laboratory of Experimental Gerontology National Institute on Aging National Institutes of Health Baltimore MD 21224 USA
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- Seth D. Crosby
- Department of Genetics Washington University School of Medicine St. Louis MO 63108 USA
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- Dudley W. Lamming
- Whitehead Institute for Biomedical Research Cambridge MA 02142 USA
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- Lellean JeBailey
- GeneGo Inc. St. Joseph MI 49085 USA
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- Susan Krzysik‐Walker
- Laboratory of Clinical Investigation National Institute on Aging National Institutes of Health Baltimore MD 21224 USA
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- Dennis T. Villareal
- Division of Geriatrics and Nutritional Science Washington University School of Medicine St. Louis MO 63108 USA
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- Miriam Capri
- CIG ‐ Interdepartmental Centre “Galvani” University of Bologna‐ ALMA MATER STUDIORUM Bologna 40126 Italy
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- Claudio Franceschi
- CIG ‐ Interdepartmental Centre “Galvani” University of Bologna‐ ALMA MATER STUDIORUM Bologna 40126 Italy
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- Yongqing Zhang
- Gene Expression and Genomics Unit National Institute on Aging National Institutes of Health Baltimore MD 21224 USA
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- Kevin Becker
- Gene Expression and Genomics Unit National Institute on Aging National Institutes of Health Baltimore MD 21224 USA
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- David M. Sabatini
- Whitehead Institute for Biomedical Research Cambridge MA 02142 USA
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- Rafael de Cabo
- Laboratory of Experimental Gerontology National Institute on Aging National Institutes of Health Baltimore MD 21224 USA
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- Luigi Fontana
- Division of Geriatrics and Nutritional Science Washington University School of Medicine St. Louis MO 63108 USA
書誌事項
- 公開日
- 2013-06-05
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/acel.12088
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Summary</jats:title><jats:p>Caloric restriction (<jats:styled-content style="fixed-case">CR</jats:styled-content>) and down‐regulation of the insulin/<jats:styled-content style="fixed-case">IGF</jats:styled-content> pathway are the most robust interventions known to increase longevity in lower organisms. However, little is known about the molecular adaptations induced by <jats:styled-content style="fixed-case">CR</jats:styled-content> in humans. Here, we report that long‐term <jats:styled-content style="fixed-case">CR</jats:styled-content> in humans inhibits the <jats:styled-content style="fixed-case">IGF</jats:styled-content>‐1/insulin pathway in skeletal muscle, a key metabolic tissue. We also demonstrate that <jats:styled-content style="fixed-case">CR</jats:styled-content> induces dramatic changes of the skeletal muscle transcriptional profile that resemble those of younger individuals. Finally, in both rats and humans, <jats:styled-content style="fixed-case">CR</jats:styled-content> evoked similar responses in the transcriptional profiles of skeletal muscle. This common signature consisted of three key pathways typically associated with longevity: <jats:styled-content style="fixed-case">IGF</jats:styled-content>‐1/insulin signaling, mitochondrial biogenesis, and inflammation. Furthermore, our data identify promising pathways for therapeutic targets to combat age‐related diseases and promote health in humans.</jats:p>
収録刊行物
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- Aging Cell
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Aging Cell 12 (4), 645-651, 2013-06-05
Wiley