Synthesis of (Z)-(arylamino)-pyrazolyl/isoxazolyl-2-propenones as tubulin targeting anticancer agents and apoptotic inducers

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<p>A new class of pyrazole conjugates were synthesized and evaluated for their antiproliferative activity in human cancer cell lines: <bold>9a</bold>, <bold>9b</bold> and <bold>9f</bold> significantly inhibited cell growth as well as tubulin polymerization.</p>

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