HIV-associated lymphomas and gamma-herpesviruses

DOI PDF 被引用文献3件
  • Antonino Carbone
    Department of Pathology, National Cancer Institute of Milan, Milan, Italy;
  • Ethel Cesarman
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY;
  • Michele Spina
    Division of Medical Oncology A, Centro di Riferimento Oncologico, Aviano, Italy; and
  • Annunziata Gloghini
    Department of Pathology, National Cancer Institute of Milan, Milan, Italy;
  • Thomas F. Schulz
    Department of Virology, Hannover Medical School, Hannover, Germany

書誌事項

公開日
2009-02-05
DOI
  • 10.1182/blood-2008-09-180315
公開者
American Society of Hematology

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説明

<jats:title>Abstract</jats:title><jats:p>Among the most common HIV-associated lymphomas are Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) with immunoblastic-plasmacytoid differentiation (also involving the central nervous system). Lymphomas occurring specifically in HIV-positive patients include primary effusion lymphoma (PEL) and its solid variants, plasmablastic lymphoma of the oral cavity type and large B-cell lymphoma arising in Kaposi sarcoma herpesvirus (KSHV)–associated multicentric Castleman disease. These lymphomas together with BL and DLBCL with immunoblastic-plasmacytoid differentiation frequently carry EBV infection and display a phenotype related to plasma cells. EBV infection occurs at different rates in different lymphoma types, whereas KSHV is specifically associated with PEL, which usually occurs in the setting of profound immunosuppression. The current knowledge about HIV-associated lymphomas can be summarized in the following key points: (1) lymphomas specifically occurring in patients with HIV infection are closely linked to other viral diseases; (2) AIDS lymphomas fall in a spectrum of B-cell differentiation where those associated with EBV or KSHV commonly exhibit plasmablastic differentiation; and (3) prognosis for patients with lymphomas and concomitant HIV infection could be improved using better combined chemotherapy protocols in-corporating anticancer treatments and antiretroviral drugs.</jats:p>

収録刊行物

  • Blood

    Blood 113 (6), 1213-1224, 2009-02-05

    American Society of Hematology

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