Human T‐cell leukemia virus type 1 Tax protein stimulates the interferon‐responsive enhancer element via NF‐κB activity<sup>1</sup>

DOI Web Site Web Site Web Site 被引用文献2件

この論文をさがす

説明

<jats:p>Gene expression in Rat‐1 fibroblast cells transformed by Tax from human T‐cell leukemia virus type 1 was studied using the reverse transcriptase polymerase chain reaction differential display technique. The analysis revealed eight genes that were upregulated and one gene that was suppressed in Tax‐transformed cells. Interestingly, at least four of the upregulated genes were interferon‐stimulated genes. Promoter analysis of the 2′,5′‐oligoadenylate synthetase gene, which was activated in both Tax‐transformed Rat‐1 cells and primary adult T‐cell leukemia cells, demonstrated that Tax indirectly activates its interferon‐responsive enhancer element in a nuclear factor‐κB pathway‐dependent manner, indicating a close association of interferon signaling with the transformation by Tax.</jats:p>

収録刊行物

  • FEBS Letters

    FEBS Letters 539 (1-3), 73-77, 2003-02-27

    Wiley

被引用文献 (2)*注記

もっと見る

問題の指摘

ページトップへ