Cytosolic Gag p24 as an Index of Productive Entry of Human Immunodeficiency Virus Type 1
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- Valérie Maréchal
- <!--label omitted: 1-->Laboratoire Rétrovirus et Transfert Génétique1 and
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- François Clavel
- <!--label omitted: 2-->Unitéd’oncologie Virale,2 CNRS URA 1157, Institut Pasteur, 75724 Paris, France
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- Jean Michel Heard
- <!--label omitted: 1-->Laboratoire Rétrovirus et Transfert Génétique1 and
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- Olivier Schwartz
- <!--label omitted: 1-->Laboratoire Rétrovirus et Transfert Génétique1 and
書誌事項
- 公開日
- 1998-03
- 権利情報
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- https://journals.asm.org/non-commercial-tdm-license
- DOI
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- 10.1128/jvi.72.3.2208-2212.1998
- 公開者
- American Society for Microbiology
この論文をさがす
説明
<jats:title>ABSTRACT</jats:title> <jats:p>We have investigated the cellular uptake of Gag p24 shortly after exposure of cells to human immunodeficiency virus (HIV) particles. In the absence of envelope glycoprotein on virions or of viral receptors or coreceptors at the cell surface, p24 was incorporated in intracellular vesicles but not detected in the cytosolic subcellular fraction. When appropriate envelope-receptor interactions could occur, the nonspecific vesicular uptake was still intense and cytosolic p24 represented 10 to 40% of total intracellular p24. The measurement of cytosolic p24 early after exposure to HIV type 1 is a reliable assay for investigating virus entry and early events leading to authentic cell infection.</jats:p>
収録刊行物
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- Journal of Virology
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Journal of Virology 72 (3), 2208-2212, 1998-03
American Society for Microbiology