Design and Fabrication of a High-Strength Hydrogel with Ideally Homogeneous Network Structure from Tetrahedron-like Macromonomers

DOI Web Site Web Site 318 Citations Open Access
  • Takamasa Sakai
    Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; The Institute for Solid State Physics, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa 277-8581, Japan; NOF Corporation, 3-3 Chidori-cho, Kawasaki-ku, Kawasaki, Kanagawa 210-0865, Japan; Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; NEXT 21, 3-38-1 Hongo, Bunkyo-ku, Tokyo 113-0033,...
  • Takuro Matsunaga
    Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; The Institute for Solid State Physics, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa 277-8581, Japan; NOF Corporation, 3-3 Chidori-cho, Kawasaki-ku, Kawasaki, Kanagawa 210-0865, Japan; Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; NEXT 21, 3-38-1 Hongo, Bunkyo-ku, Tokyo 113-0033,...
  • Yuji Yamamoto
    Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; The Institute for Solid State Physics, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa 277-8581, Japan; NOF Corporation, 3-3 Chidori-cho, Kawasaki-ku, Kawasaki, Kanagawa 210-0865, Japan; Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; NEXT 21, 3-38-1 Hongo, Bunkyo-ku, Tokyo 113-0033,...
  • Shigeki Suzuki
    Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; The Institute for Solid State Physics, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa 277-8581, Japan; NOF Corporation, 3-3 Chidori-cho, Kawasaki-ku, Kawasaki, Kanagawa 210-0865, Japan; Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; NEXT 21, 3-38-1 Hongo, Bunkyo-ku, Tokyo 113-0033,...
  • Chika Ito
    Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; The Institute for Solid State Physics, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa 277-8581, Japan; NOF Corporation, 3-3 Chidori-cho, Kawasaki-ku, Kawasaki, Kanagawa 210-0865, Japan; Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; NEXT 21, 3-38-1 Hongo, Bunkyo-ku, Tokyo 113-0033,...
  • Ryo Yoshida
    Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; The Institute for Solid State Physics, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa 277-8581, Japan; NOF Corporation, 3-3 Chidori-cho, Kawasaki-ku, Kawasaki, Kanagawa 210-0865, Japan; Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; NEXT 21, 3-38-1 Hongo, Bunkyo-ku, Tokyo 113-0033,...
  • Nobuo Sasaki
    Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; The Institute for Solid State Physics, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa 277-8581, Japan; NOF Corporation, 3-3 Chidori-cho, Kawasaki-ku, Kawasaki, Kanagawa 210-0865, Japan; Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; NEXT 21, 3-38-1 Hongo, Bunkyo-ku, Tokyo 113-0033,...
  • Ung-il Chung
    Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; The Institute for Solid State Physics, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa 277-8581, Japan; NOF Corporation, 3-3 Chidori-cho, Kawasaki-ku, Kawasaki, Kanagawa 210-0865, Japan; Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; NEXT 21, 3-38-1 Hongo, Bunkyo-ku, Tokyo 113-0033,...
  • Mitsuhiro Shibayama
    Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; The Institute for Solid State Physics, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa 277-8581, Japan; NOF Corporation, 3-3 Chidori-cho, Kawasaki-ku, Kawasaki, Kanagawa 210-0865, Japan; Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; NEXT 21, 3-38-1 Hongo, Bunkyo-ku, Tokyo 113-0033,...

Bibliographic Information

Published
2008-06-21
Rights Information
  • https://creativecommons.org/licenses/by/4.0/
DOI
  • 10.1021/ma800476x
Publisher
American Chemical Society (ACS)

Search this article

Description

As a new class of high-strength hydrogels, we designed a tetra-PEG gel by combining two symmetrical tetrahedron-like macromonomers of the same size. Because the nanostructural unit of the gel network was defined by the length of the tetrahedral PEG arm, the gel had a homogeneous structure and resultant high mechanical strength comparable to that of native articular cartilage. Furthermore, since the gel was formed by mixing two biocompatible macromonomer solutions, the gelation reaction itself and the resultant gel were also biocompatible. The breaking strength had local maxima at the overlap concentration of the macromonomers (C*) and at 2C*. Dynamic light scattering measurement indicated the near absence of inhomogeneities in the network at C*. Thus, we successfully designed and fabricated a high-strength hydrogel by controlling the homogeneity of network structure for the first time, which will lead to multiplied effects, i.e., contributing to the understanding of ideal networks, providing a universal s...

Journal

  • Macromolecules

    Macromolecules 41 (14), 5379-5384, 2008-06-21

    American Chemical Society (ACS)

Citations (318)*help

See more

Details 詳細情報について

Report a problem

Back to top