The Maternal Nucleolus Is Essential for Early Embryonic Development in Mammals

DOI Web Site PubMed 被引用文献21件
  • Sugako Ogushi
    Graduate School of Science and Technology, Kobe University, Kobe 657-8501, Japan.
  • Chiara Palmieri
    Graduate School of Science and Technology, Kobe University, Kobe 657-8501, Japan.
  • Helena Fulka
    Graduate School of Science and Technology, Kobe University, Kobe 657-8501, Japan.
  • Mitinori Saitou
    Graduate School of Science and Technology, Kobe University, Kobe 657-8501, Japan.
  • Takashi Miyano
    Graduate School of Science and Technology, Kobe University, Kobe 657-8501, Japan.
  • Josef Fulka
    Graduate School of Science and Technology, Kobe University, Kobe 657-8501, Japan.

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<jats:p>With fertilization, the paternal and maternal contributions to the zygote are not equal. The oocyte and spermatozoon are equipped with complementary arsenals of cellular structures and molecules necessary for the creation of a developmentally competent embryo. We show that the nucleolus is exclusively of maternal origin. The maternal nucleolus is not necessary for oocyte maturation; however, it is necessary for the formation of pronuclear nucleoli after fertilization or parthenogenetic activation and is essential for further embryonic development. In addition, the nucleolus in the embryo produced by somatic cell nuclear transfer originates from the oocyte, demonstrating that the maternal nucleolus supports successful embryonic development.</jats:p>

収録刊行物

  • Science

    Science 319 (5863), 613-616, 2008-02

    American Association for the Advancement of Science (AAAS)

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