Common Carotid Intima-Media Thickness Measurements Do Not Improve Cardiovascular Risk Prediction in Individuals With Elevated Blood Pressure

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  • Michiel L. Bots
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Karlijn A. Groenewegen
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Todd J. Anderson
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Annie R. Britton
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Jacqueline M. Dekker
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Gunnar Engström
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Greg W. Evans
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Jacqueline de Graaf
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Diederick E. Grobbee
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Bo Hedblad
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Albert Hofman
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Suzanne Holewijn
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Ai Ikeda
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Maryam Kavousi
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Kazuo Kitagawa
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Akihiko Kitamura
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • M. Arfan Ikram
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Eva M. Lonn
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Matthias W. Lorenz
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Ellisiv B. Mathiesen
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Giel Nijpels
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Shuhei Okazaki
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Daniel H. O’Leary
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Joseph F. Polak
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Jacqueline F. Price
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Christine Robertson
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Christopher M. Rembold
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Maria Rosvall
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Tatjana Rundek
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Jukka T. Salonen
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Matthias Sitzer
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Coen D.A. Stehouwer
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Oscar H. Franco
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Sanne A.E. Peters
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...
  • Hester M. den Ruijter
    From the Julius Center for Health Sciences and Primary Care (M.L.B., K.A.G., D.E.G., S.A.E.P., H.M.d.R.) and Department of Experimental Cardiology (H.M.d.R.), University Medical Center Utrecht, The Netherlands; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada (T.J.A.); Department of Epidemiology and Public Health University College London, UK (A.R.B.); Institute for Health and Care Research, VU University Medical Center, Amsterdam,...

書誌事項

タイトル別名
  • The USE-IMT Collaboration

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説明

<jats:p>Carotid intima-media thickness (CIMT) is a marker of cardiovascular risk. It is unclear whether measurement of mean common CIMT improves 10-year risk prediction of first-time myocardial infarction or stroke in individuals with elevated blood pressure. We performed an analysis among individuals with elevated blood pressure (ie, a systolic blood pressure ≥140 mm Hg and a diastolic blood pressure ≥ 90 mm Hg) in USE-IMT, a large ongoing individual participant data meta-analysis. We refitted the risk factors of the Framingham Risk Score on asymptomatic individuals (baseline model) and expanded this model with mean common CIMT (CIMT model) measurements. From both models, 10-year risks to develop a myocardial infarction or stroke were estimated. In individuals with elevated blood pressure, we compared discrimination and calibration of the 2 models and calculated the net reclassification improvement (NRI). We included 17 254 individuals with elevated blood pressure from 16 studies. During a median follow-up of 9.9 years, 2014 first-time myocardial infarctions or strokes occurred. The C-statistics of the baseline and CIMT models were similar (0.73). NRI with the addition of mean common CIMT was small and not significant (1.4%; 95% confidence intervals, −1.1 to 3.7). In those at intermediate risk (n=5008, 10-year absolute risk of 10% to 20%), the NRI was 5.6% (95% confidence intervals, 1.6–10.4). There is no added value of measurement of mean common CIMT in individuals with elevated blood pressure for improving cardiovascular risk prediction. For those at intermediate risk, the addition of mean common CIMT to an existing cardiovascular risk score is small but statistically significant.</jats:p>

収録刊行物

  • Hypertension

    Hypertension 63 (6), 1173-1181, 2014-06

    Ovid Technologies (Wolters Kluwer Health)

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