Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment

DOI Web Site 2 Citations
  • Gordon F. Heidkamp
    Department of Dermatology, Laboratory of Dendritic Cell Biology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University Hospital Erlangen, Erlangen, Germany.
  • Jil Sander
    LIMES (Life and Medical Sciences) Institute, Genomics and Immunoregulation, University of Bonn, Bonn, Germany.
  • Christian H. K. Lehmann
    Department of Dermatology, Laboratory of Dendritic Cell Biology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University Hospital Erlangen, Erlangen, Germany.
  • Lukas Heger
    Department of Dermatology, Laboratory of Dendritic Cell Biology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University Hospital Erlangen, Erlangen, Germany.
  • Nathalie Eissing
    Department of Dermatology, Laboratory of Dendritic Cell Biology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University Hospital Erlangen, Erlangen, Germany.
  • Anna Baranska
    Department of Dermatology, Laboratory of Dendritic Cell Biology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University Hospital Erlangen, Erlangen, Germany.
  • Jennifer J. Lühr
    Department of Dermatology, Laboratory of Dendritic Cell Biology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University Hospital Erlangen, Erlangen, Germany.
  • Alana Hoffmann
    Department of Dermatology, Laboratory of Dendritic Cell Biology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University Hospital Erlangen, Erlangen, Germany.
  • Katharina C. Reimer
    Department of Dermatology, Laboratory of Dendritic Cell Biology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University Hospital Erlangen, Erlangen, Germany.
  • Anja Lux
    Department of Biology, Chair of Genetics, FAU, Erlangen, Germany.
  • Stephan Söder
    Department of Pathology, FAU, University Hospital Erlangen, Erlangen, Germany.
  • Arndt Hartmann
    Department of Pathology, FAU, University Hospital Erlangen, Erlangen, Germany.
  • Johannes Zenk
    Department of Otorhinolaryngology, Klinikum Augsburg Süd, Augsburg, Germany.
  • Thomas Ulas
    LIMES (Life and Medical Sciences) Institute, Genomics and Immunoregulation, University of Bonn, Bonn, Germany.
  • Naomi McGovern
    Singapore Immunology Network, A*STAR (Agency for Science Technology and Research), Singapore, Singapore.
  • Christoph Alexiou
    Section for Experimental Oncology and Nanomedicine, Department of Otorhinolaryngology, Head and Neck Surgery, Else Kröner-Fresenius-Stiftung-Professorship, FAU, University Hospital Erlangen, Erlangen, Germany.
  • Bernd Spriewald
    Department of Medicine 5, Hematology and Oncology, FAU, University Hospital Erlangen, Erlangen, Germany.
  • Andreas Mackensen
    Department of Medicine 5, Hematology and Oncology, FAU, University Hospital Erlangen, Erlangen, Germany.
  • Gerold Schuler
    Department of Dermatology, FAU, University Hospital Erlangen, Erlangen, Germany.
  • Burkhard Schauf
    Department of Obstetrics and Gynecology, Sozialstiftung Bamberg, Bamberg, Germany.
  • Anja Forster
    Department of Obstetrics and Gynecology, Sozialstiftung Bamberg, Bamberg, Germany.
  • Roland Repp
    Medical Department 2, Städtisches Krankenhaus Kiel, Kiel, Germany.
  • Peter A. Fasching
    Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, FAU, University Hospital Erlangen, Erlangen, Germany.
  • Ariawan Purbojo
    Department of Pediatric Cardiac Surgery, FAU, University Hospital Erlangen, Erlangen, Germany.
  • Robert Cesnjevar
    Department of Pediatric Cardiac Surgery, FAU, University Hospital Erlangen, Erlangen, Germany.
  • Evelyn Ullrich
    LOEWE Center for Cell and Gene Therapy, Goethe University, Frankfurt, Germany.
  • Florent Ginhoux
    Singapore Immunology Network, A*STAR (Agency for Science Technology and Research), Singapore, Singapore.
  • Andreas Schlitzer
    LIMES (Life and Medical Sciences) Institute, Genomics and Immunoregulation, University of Bonn, Bonn, Germany.
  • Falk Nimmerjahn
    Department of Biology, Chair of Genetics, FAU, Erlangen, Germany.
  • Joachim L. Schultze
    LIMES (Life and Medical Sciences) Institute, Genomics and Immunoregulation, University of Bonn, Bonn, Germany.
  • Diana Dudziak
    Department of Dermatology, Laboratory of Dendritic Cell Biology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University Hospital Erlangen, Erlangen, Germany.

Description

<jats:p>Transcriptional identity of human dendritic cell subsets is mainly dictated by ontogeny rather than by signals derived from the cells’ final tissue microenvironment.</jats:p>

Journal

  • Science Immunology

    Science Immunology 1 (6), 40-, 2016-12-23

    American Association for the Advancement of Science (AAAS)

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