Analysis of <i>Fusobacterium</i> persistence and antibiotic response in colorectal cancer
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- Susan Bullman
- Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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- Chandra S. Pedamallu
- Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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- Ewa Sicinska
- Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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- Thomas E. Clancy
- Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
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- Xiaoyang Zhang
- Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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- Diana Cai
- Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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- Donna Neuberg
- Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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- Katherine Huang
- Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
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- Fatima Guevara
- Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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- Timothy Nelson
- Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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- Otari Chipashvili
- Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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- Timothy Hagan
- Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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- Mark Walker
- Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
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- Aruna Ramachandran
- Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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- Begoña Diosdado
- Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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- Garazi Serna
- Vall d’Hebron University Hospital, Vall d’Hebron Institute of Oncology, Barcelona, CIBERONC, Universitat Autònoma de Barcelona, Spain.
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- Nuria Mulet
- Vall d’Hebron University Hospital, Vall d’Hebron Institute of Oncology, Barcelona, CIBERONC, Universitat Autònoma de Barcelona, Spain.
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- Stefania Landolfi
- Vall d’Hebron University Hospital, Vall d’Hebron Institute of Oncology, Barcelona, CIBERONC, Universitat Autònoma de Barcelona, Spain.
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- Santiago Ramon y Cajal
- Vall d’Hebron University Hospital, Vall d’Hebron Institute of Oncology, Barcelona, CIBERONC, Universitat Autònoma de Barcelona, Spain.
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- Roberta Fasani
- Vall d’Hebron University Hospital, Vall d’Hebron Institute of Oncology, Barcelona, CIBERONC, Universitat Autònoma de Barcelona, Spain.
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- Andrew J. Aguirre
- Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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- Kimmie Ng
- Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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- Elena Élez
- Vall d’Hebron University Hospital, Vall d’Hebron Institute of Oncology, Barcelona, CIBERONC, Universitat Autònoma de Barcelona, Spain.
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- Shuji Ogino
- Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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- Josep Tabernero
- Vall d’Hebron University Hospital, Vall d’Hebron Institute of Oncology, Barcelona, CIBERONC, Universitat Autònoma de Barcelona, Spain.
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- Charles S. Fuchs
- Yale Cancer Center, Yale School of Medicine, New Haven, CT 06520, USA.
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- William C. Hahn
- Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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- Paolo Nuciforo
- Vall d’Hebron University Hospital, Vall d’Hebron Institute of Oncology, Barcelona, CIBERONC, Universitat Autònoma de Barcelona, Spain.
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- Matthew Meyerson
- Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
書誌事項
- 公開日
- 2017-12-15
- DOI
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- 10.1126/science.aal5240
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:title>Bacteria go the distance in cancer</jats:title> <jats:p> The bacterial species <jats:italic>Fusobacterium nucleatum</jats:italic> is associated with a subset of human colorectal cancers, but its role in tumorigenesis is unclear. Studying patient samples, Bullman <jats:italic>et al.</jats:italic> found that <jats:italic>F. nucleatum</jats:italic> and certain co-occurring bacteria were present not only in primary tumors but also in distant metastases. Preliminary evidence suggests that the bacterium is localized primarily within the metastatic cancer cells rather than in the stroma. Antibiotic treatment of mice carrying xenografts of <jats:italic>F. nucleatum</jats:italic> –positive human colorectal cancer slowed tumor growth, consistent with a causal role for the bacterium in tumorigenesis. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6369" page="1443" related-article-type="in-this-issue" vol="358" xlink:href="10.1126/science.aal5240">1443</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 358 (6369), 1443-1448, 2017-12-15
American Association for the Advancement of Science (AAAS)
