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- Oscar Marín
- Unidad de Neurobiología del Desarrollo, Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas-Universidad Miguel Hernández, 03550 San Juan de Alicante, Spain;
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- John L.R. Rubenstein
- Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, Langley Porter Psychiatric Institute, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, California 94143;
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説明
<jats:p>▪ Abstract The forebrain comprises an intricate set of structures that are required for some of the most complex and evolved functions of the mammalian brain. As a reflection of its complexity, cell migration in the forebrain is extremely elaborated, with widespread dispersion of cells across multiple functionally distinct areas. Two general modes of migration are distinguished in the forebrain: radial migration, which establishes the general cytoarchitectonical framework of the different forebrain subdivisions; and tangential migration, which increases the cellular complexity of forebrain circuits by allowing the dispersion of multiple neuronal types. Here, we review the cellular and molecular mechanisms underlying each of these types of migrations and discuss how emerging concepts in neuronal migration are reshaping our understanding of forebrain development in normal and pathological situations.</jats:p>
収録刊行物
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- Annual Review of Neuroscience
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Annual Review of Neuroscience 26 (1), 441-483, 2003-03
Annual Reviews