Genistein, a dietary-derived inhibitor of in vitro angiogenesis.

T Fotsis, M Pepper, H Adlercreutz, G Fleischmann, T Hase, R Montesano, L Schweigerer

doi:10.1073/pnas.90.7.2690

<jats:p>Consumption of a plant-based diet can prevent the development and progression of chronic diseases that are associated with extensive neovascularization; however, little is known about the mechanisms. To determine whether prevention might be associated with dietary-derived angiogenesis inhibitors, we have fractionated urine of healthy human subjects consuming a plant-based diet and examined the fractions for their abilities to inhibit the proliferation of vascular endothelial cells. Using gas chromatography-mass spectrometry, we showed that one of the most potent fractions contained several isoflavonoids, which we subsequently synthesized. Of all synthetic compounds, the isoflavonoid genistein was the most potent and inhibited endothelial cell proliferation and in vitro angiogenesis at concentrations giving half-maximal inhibition of 5 and 150 microM, respectively. As we have previously demonstrated, genistein concentrations in urine of subjects consuming a plant-based diet are in the micromolar range, while those of subjects consuming a traditional Western diet are lower by a factor of > 30. The high excretion of genistein in urine of vegetarians and our present results suggest that genistein may contribute to the preventive effect of a plant-based diet on chronic diseases, including solid tumors, by inhibiting neovascularization. Thus, genistein may represent a member of a new class of dietary-derived anti-angiogenic compounds.</jats:p>

Genistein, a dietary-derived inhibitor of in vitro angiogenesis.

抄録

収録刊行物

被引用文献 (23)*注記

キーワード

詳細情報詳細情報について

書き出し

問題の指摘

Genistein, a dietary-derived inhibitor of in vitro angiogenesis.

抄録

収録刊行物

被引用文献 (23)*注記

キーワード

詳細情報 詳細情報について

書き出し

問題の指摘

詳細情報詳細情報について