Hepatocyte growth factor is a synergistic factor for the growth of hematopoietic progenitor cells

DOI PDF 被引用文献2件
  • TE Kmiecik
    ABL-Basic Research Program, Program Resources, Inc/DynCorp, Inc, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21701.
  • JR Keller
    ABL-Basic Research Program, Program Resources, Inc/DynCorp, Inc, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21701.
  • E Rosen
    ABL-Basic Research Program, Program Resources, Inc/DynCorp, Inc, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21701.
  • GF Vande Woude
    ABL-Basic Research Program, Program Resources, Inc/DynCorp, Inc, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21701.

書誌事項

公開日
1992-11-15
DOI
  • 10.1182/blood.v80.10.2454.2454
公開者
American Society of Hematology

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説明

<jats:title>Abstract</jats:title> <jats:p>Bone marrow (BM) stromal cells, which include macrophages, fibroblasts, endothelial cells, and adipocytes, have been shown to produce several factors that modulate the growth of BM progenitors. Hepatocyte growth factor (HGF) is a fibroblast-derived factor and has recently been shown to be a ligand for the c-met proto-oncogene, a member of the receptor class of tyrosine kinases. c-met messenger RNA (mRNA) is predominantly expressed in epithelial cells, but has been detected in several murine hematopoietic progenitor cell lines, suggesting that HGF and met might function during hematopoiesis. Here, BM cells were found to express both met mRNA and protein. Moreover, HGF was shown to synergize with interleukin-3 and granulocyte-macrophage colony-stimulating factor to stimulate colony formation of hematopoietic progenitor cells in vitro. These results show that, in addition to its activity on epithelial cells, HGF is a new member of the functionally related group of factors that modulate hematopoiesis.</jats:p>

収録刊行物

  • Blood

    Blood 80 (10), 2454-2457, 1992-11-15

    American Society of Hematology

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