Molecular Basis for High Virulence of Hong Kong H5N1 Influenza A Viruses
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- Masato Hatta
- Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin–Madison, 2015 Linden Drive, Madison, WI 53706, USA.
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- Peng Gao
- Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin–Madison, 2015 Linden Drive, Madison, WI 53706, USA.
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- Peter Halfmann
- Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin–Madison, 2015 Linden Drive, Madison, WI 53706, USA.
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- Yoshihiro Kawaoka
- Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin–Madison, 2015 Linden Drive, Madison, WI 53706, USA.
書誌事項
- 公開日
- 2001-09-07
- DOI
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- 10.1126/science.1062882
- 公開者
- American Association for the Advancement of Science (AAAS)
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説明
<jats:p>In 1997, an H5N1 influenza A virus was transmitted from birds to humans in Hong Kong, killing 6 of the 18 people infected. When mice were infected with the human isolates, two virulence groups became apparent. Using reverse genetics, we showed that a mutation at position 627 in the PB2 protein influenced the outcome of infection in mice. Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection.</jats:p>
収録刊行物
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- Science
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Science 293 (5536), 1840-1842, 2001-09-07
American Association for the Advancement of Science (AAAS)
