書誌事項
- 公開日
- 2002-09
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1016/s0736-0266(02)00017-7
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>We have developed a method to study the molecular basis of intramembranous fracture healing. Unlike intramedullary rods that permit rotation of the fractured bone segments, our murine model relies on an external fixation device to provide stabilization. In this study we compare stabilized fracture callus tissues with callus tissues from non‐stabilized fractures during the inflammatory, soft callus, hard callus, and remodeling stages of healing. Histological analyses indicate that stabilized fractures heal with virtually no evidence of cartilage whereas non‐stabilized fractures produce abundant cartilage at the fracture site. Expression patterns of <jats:italic>collagen type IIa (colIIa)</jats:italic> and <jats:italic>osteocalcin (oc)</jats:italic> reveal that mesenchymal cells at the fracture site commit to either a chondrogenic or an osteogenic lineage during the earliest stages of healing. The mechanical environment influences this cell fate decision, since mesenchymal cells in a stabilized fracture express <jats:italic>oc</jats:italic> and fail to express <jats:italic>colIIa</jats:italic>. Future studies will use this murine model of intramembranous fracture healing to explore, at a molecular level, how the mechanical environment exerts its influence on healing of a fracture.</jats:p><jats:p>© 2002 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.</jats:p>
収録刊行物
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- Journal of Orthopaedic Research
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Journal of Orthopaedic Research 20 (5), 1091-1098, 2002-09
Wiley
