EGF Decreases the Abundance of MicroRNAs That Restrain Oncogenic Transcription Factors
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- Roi Avraham
- Department of Biological Regulation, Weizmann Institute of Science, 76100 Rehovot, Israel.
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- Aldema Sas-Chen
- Department of Biological Regulation, Weizmann Institute of Science, 76100 Rehovot, Israel.
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- Ohad Manor
- Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 76100 Rehovot, Israel.
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- Israel Steinfeld
- Department of Computer Sciences, Technion–Israel Institute of Technology, 32000 Haifa, Israel.
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- Reut Shalgi
- Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel.
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- Gabi Tarcic
- Department of Biological Regulation, Weizmann Institute of Science, 76100 Rehovot, Israel.
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- Noa Bossel
- Department of Physics of Complex Systems, Weizmann Institute of Science, 76100 Rehovot, Israel.
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- Amit Zeisel
- Department of Physics of Complex Systems, Weizmann Institute of Science, 76100 Rehovot, Israel.
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- Ido Amit
- Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
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- Yaara Zwang
- Department of Biological Regulation, Weizmann Institute of Science, 76100 Rehovot, Israel.
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- Espen Enerly
- Faculty of Medicine, University of Oslo, Montebello NO-0317, and Department of Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, 0027 Oslo, Norway.
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- Hege G. Russnes
- Department of Pathology, Oslo University Hospital, N-0310 Oslo, Norway.
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- Francesca Biagioni
- Translational Oncogenomic Unit, Regina Elena Cancer Institute, 00128 Rome, Italy.
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- Marcella Mottolese
- Pathology Unit, Regina Elena Cancer Institute, 00128 Rome, Italy.
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- Sabrina Strano
- Molecular Chemoprevention Group, Regina Elena Cancer Institute, 00128 Rome, Italy.
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- Giovanni Blandino
- Translational Oncogenomic Unit, Regina Elena Cancer Institute, 00128 Rome, Italy.
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- Anne-Lise Børresen-Dale
- Faculty of Medicine, University of Oslo, Montebello NO-0317, and Department of Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, 0027 Oslo, Norway.
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- Yitzhak Pilpel
- Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel.
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- Zohar Yakhini
- Department of Computer Sciences, Technion–Israel Institute of Technology, 32000 Haifa, Israel.
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- Eran Segal
- Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 76100 Rehovot, Israel.
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- Yosef Yarden
- Department of Biological Regulation, Weizmann Institute of Science, 76100 Rehovot, Israel.
説明
<jats:p>Some cancers showed decreased abundance of a subset of EGF-regulated microRNAs, which allows the production of oncogenic transcription factors.</jats:p>
収録刊行物
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- Science Signaling
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Science Signaling 3 (124), 2010-06
American Association for the Advancement of Science (AAAS)