Pulmonary Surfactant Protein D in Sera and Bronchoalveolar Lavage Fluids

DOI PDF PubMed 被引用文献37件
  • Y Honda
    Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
  • Y Kuroki
    Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
  • E Matsuura
    Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
  • H Nagae
    Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
  • H Takahashi
    Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
  • T Akino
    Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
  • S Abe
    Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan

書誌事項

公開日
1995-12-01
権利情報
  • https://academic.oup.com/pages/standard-publication-reuse-rights
DOI
  • 10.1164/ajrccm.152.6.8520747
公開者
Oxford University Press (OUP)

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<jats:title>Abstract</jats:title> <jats:p>Pulmonary surfactant protein D (SP-D) is a hydrophilic glycoprotein with a reduced molecular mass of 43 kDa and a member of the C-type lectin superfamily, along with mannose-binding proteins and surfactant protein A (SP-A). We have recently prepared monoclonal antibodies against human SP-D and developed an enzyme-linked immunosorbent assay (ELISA). In this study, the levels of SP-D in sera and bronchoalveolar lavage (BAL) fluids of patients with lung diseases were determined by ELISA, using human recombinant SP-D as a standard. We demonstrated that the concentrations of SP-D in sera are prominently increased in patients with idiopathic pulmonary fibrosis (IPF), interstitial pneumonia with collagen disease (IPCD), and pulmonary alveolar proteinosis (PAP). Patients with IPF, IPCD, and PAP exhibited levels of serum SP-D 5.1-fold, 7.2-fold, and 7.0-fold, respectively, of those in healthy volunteers; 91.5% of the patients with IPF, 81.3% with IPCD, and 100% with PAP exhibited serum SP-D levels that exceeded the cut-off value (mean + 2 SD of control value). Serum SP-D levels appeared to reflect the disease activity of IPF and IPCD and the disease severity of PAP. High levels of SP-D in BAL fluids were shown in patients with PAP, but not with IPF and IPCD. We conclude that measurement of SP-D in sera can provide an easily identifiable and useful clinical marker for the diagnosis of IPF, IPCD, and PAP, and can predict the disease activity of IPF and IPCD and the disease severity of PAP.</jats:p>

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