Genomic characterization of non-O1, non-O139 <i>Vibrio cholerae</i> reveals genes for a type III secretion system
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- Michelle Dziejman
- Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115; Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1212, Bangladesh; The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Harvard Partners Genome Center, 65 Landsdowne Street, Cambridge, MA 02139; and Department of Genetics, Harvard Medical School, Brigham and Women's Hospital, New Research Building, 77...
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- Davide Serruto
- Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115; Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1212, Bangladesh; The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Harvard Partners Genome Center, 65 Landsdowne Street, Cambridge, MA 02139; and Department of Genetics, Harvard Medical School, Brigham and Women's Hospital, New Research Building, 77...
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- Vincent C. Tam
- Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115; Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1212, Bangladesh; The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Harvard Partners Genome Center, 65 Landsdowne Street, Cambridge, MA 02139; and Department of Genetics, Harvard Medical School, Brigham and Women's Hospital, New Research Building, 77...
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- Derek Sturtevant
- Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115; Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1212, Bangladesh; The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Harvard Partners Genome Center, 65 Landsdowne Street, Cambridge, MA 02139; and Department of Genetics, Harvard Medical School, Brigham and Women's Hospital, New Research Building, 77...
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- Pornphan Diraphat
- Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115; Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1212, Bangladesh; The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Harvard Partners Genome Center, 65 Landsdowne Street, Cambridge, MA 02139; and Department of Genetics, Harvard Medical School, Brigham and Women's Hospital, New Research Building, 77...
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- Shah M. Faruque
- Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115; Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1212, Bangladesh; The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Harvard Partners Genome Center, 65 Landsdowne Street, Cambridge, MA 02139; and Department of Genetics, Harvard Medical School, Brigham and Women's Hospital, New Research Building, 77...
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- M. Hasibur Rahman
- Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115; Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1212, Bangladesh; The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Harvard Partners Genome Center, 65 Landsdowne Street, Cambridge, MA 02139; and Department of Genetics, Harvard Medical School, Brigham and Women's Hospital, New Research Building, 77...
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- John F. Heidelberg
- Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115; Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1212, Bangladesh; The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Harvard Partners Genome Center, 65 Landsdowne Street, Cambridge, MA 02139; and Department of Genetics, Harvard Medical School, Brigham and Women's Hospital, New Research Building, 77...
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- Jeremy Decker
- Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115; Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1212, Bangladesh; The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Harvard Partners Genome Center, 65 Landsdowne Street, Cambridge, MA 02139; and Department of Genetics, Harvard Medical School, Brigham and Women's Hospital, New Research Building, 77...
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- Li Li
- Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115; Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1212, Bangladesh; The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Harvard Partners Genome Center, 65 Landsdowne Street, Cambridge, MA 02139; and Department of Genetics, Harvard Medical School, Brigham and Women's Hospital, New Research Building, 77...
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- Kate T. Montgomery
- Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115; Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1212, Bangladesh; The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Harvard Partners Genome Center, 65 Landsdowne Street, Cambridge, MA 02139; and Department of Genetics, Harvard Medical School, Brigham and Women's Hospital, New Research Building, 77...
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- George Grills
- Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115; Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1212, Bangladesh; The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Harvard Partners Genome Center, 65 Landsdowne Street, Cambridge, MA 02139; and Department of Genetics, Harvard Medical School, Brigham and Women's Hospital, New Research Building, 77...
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- Raju Kucherlapati
- Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115; Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1212, Bangladesh; The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Harvard Partners Genome Center, 65 Landsdowne Street, Cambridge, MA 02139; and Department of Genetics, Harvard Medical School, Brigham and Women's Hospital, New Research Building, 77...
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- John J. Mekalanos
- Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115; Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1212, Bangladesh; The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Harvard Partners Genome Center, 65 Landsdowne Street, Cambridge, MA 02139; and Department of Genetics, Harvard Medical School, Brigham and Women's Hospital, New Research Building, 77...
書誌事項
- 公開日
- 2005-02-22
- DOI
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- 10.1073/pnas.0409918102
- 公開者
- Proceedings of the National Academy of Sciences
この論文をさがす
説明
<jats:p> Non-O1, non-O139 <jats:italic>Vibrio cholerae</jats:italic> can cause gastroenteritis and extraintestinal infections, but, unlike O1 and O139 strains of <jats:italic>V. cholerae</jats:italic> , little is known about the virulence gene content of non-O1, non-O139 strains and their phylogenetic relationship to other pathogenic <jats:italic>V. cholerae</jats:italic> . Comparative genomic microarray analysis of four pathogenic non-O1, non-O139 strains indicates that these strains are quite divergent from O1 and O139 strains. Genomic sequence analysis of a non-O1, non-O139 strain (AM-19226) that appeared particularly pathogenic in experimental animals suggests that this strain carries a type III secretion system (TTSS) that is related to the TTSS2 gene cluster found in a pandemic clone of <jats:italic>Vibrio parahaemolyticus</jats:italic> . The genes for this <jats:italic>V. cholerae</jats:italic> TTSS system appear to be present in many clinical and environmental non-O1, non-O139 strains, including at least one clone that is globally distributed. We hypothesize that the TTSS present in some pathogenic strains of non-O1, non-O139 <jats:italic>V. cholerae</jats:italic> may be involved in the virulence and environmental fitness of these strains. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 102 (9), 3465-3470, 2005-02-22
Proceedings of the National Academy of Sciences
