Topical Colchicine Gel versus Diclofenac Sodium Gel for the Treatment of Actinic Keratoses: A Randomized, Double-Blind Study

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  • Gita Faghihi
    Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  • Azam Elahipoor
    Department of Dermatology, Qom University of Medical Sciences, Qom, Iran
  • Fariba Iraji
    Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  • Shadi Behfar
    Department of Dermatology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  • Bahareh Abtahi-Naeini
    Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran

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<jats:p><jats:italic>Introduction</jats:italic>. Actinic keratoses (AKs), a premalignant skin lesion, are a common lesion in fair skin. Although destructive treatment remains the gold standard for AKs, medical therapies may be preferable due to the comfort and reliability .This study aims to compare the effects of topical 1% colchicine gel and 3% diclofenac sodium gel in AKs.<jats:italic>Materials and Methods</jats:italic>. In this randomized double-blind study, 70 lesions were selected. Patients were randomized before receiving either 1% colchicine gel or 3% diclofenac sodium cream twice a day for 6 weeks. Patients were evaluated in terms of their lesion size, treatment complications, and recurrence at 7, 30, 60, and 120 days after treatment.<jats:italic>Results</jats:italic>. The mean of changes in the size was significant in both groups both before and after treatment (<0.001). The mean lesion size before treatment and at 30, 60, and 120 days was not different between the two groups (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>p</mml:mi></mml:mrow></mml:math>> 0.05). No case of erythema was seen in the colchicine group, while erythema was seen in 22.9% (eight cases) of patients in the diclofenac sodium group (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mrow><mml:mi>p</mml:mi></mml:mrow></mml:math>= 0.005).<jats:italic>Conclusions</jats:italic>. 1% colchicine gel was a safe and effective medication with fewer side effects and lack of recurrence of the lesion.</jats:p>

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