Sequence dependence in solid-phase-synthesis-cyclization-cleavage for Cyclo(-arginyl-glycyl-aspartyl-phenylglycyl-)

書誌事項

公開日
1992-03
権利情報
  • https://www.elsevier.com/tdm/userlicense/1.0/
DOI
  • 10.1016/s0040-4039(00)91652-6
公開者
Elsevier BV

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説明

Abstract A cyclic tetrapeptide with inhibitory activity toward cell adhesion, cyclo(-Arg-Gly-Asp-Phg-) (phg, phenylglycine) (IC 50 = 10 μM), was synthesized. The cyclization-cleavage of the protected precursor from the oxime resin significantly depended on the sequences of the linear tetrapeptides assembled by solid-phase-synthesis on the resin.

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