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- Renu Garg
- Department of Biology, University of North Carolina at Charlotte , Charlotte, NC 28223
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- Ignacio J Juncadella
- Department of Biology, University of North Carolina at Charlotte , Charlotte, NC 28223
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- Nandhini Ramamoorthi
- Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine , New Haven, CT 06520
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- Ashish
- Department of Chemistry, University of North Carolina at Charlotte , Charlotte, NC 28223
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- Shobana K Ananthanarayanan
- Department of Biology, University of North Carolina at Charlotte , Charlotte, NC 28223
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- Venetta Thomas
- Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine , New Haven, CT 06520
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- Mercedes Rincón
- Department of Internal Medicine, Section of Immunobiology, University of Vermont , Burlington, VT 05405
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- Joanna K Krueger
- Department of Chemistry, University of North Carolina at Charlotte , Charlotte, NC 28223
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- Erol Fikrig
- Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine , New Haven, CT 06520
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- Christopher M Yengo
- Department of Biology, University of North Carolina at Charlotte , Charlotte, NC 28223
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- Juan Anguita
- Department of Biology, University of North Carolina at Charlotte , Charlotte, NC 28223
書誌事項
- 公開日
- 2006-11
- 権利情報
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- https://academic.oup.com/pages/standard-publication-reuse-rights
- DOI
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- 10.4049/jimmunol.177.10.6579
- 公開者
- Oxford University Press (OUP)
この論文をさがす
説明
<jats:title>Abstract</jats:title> <jats:p>Salp15 is an Ixodes scapularis salivary protein that inhibits CD4+ T cell activation through the repression of TCR ligation-triggered calcium fluxes and IL-2 production. We show in this study that Salp15 binds specifically to the CD4 coreceptor on mammalian host T cells. Salp15 specifically associates through its C-terminal residues with the outermost two extracellular domains of CD4. Upon binding to CD4, Salp15 inhibits the subsequent TCR ligation-induced T cell signaling at the earliest steps including tyrosine phosphorylation of the Src kinase Lck, downstream effector proteins, and lipid raft reorganization. These results provide a molecular basis to understanding the immunosuppressive activity of Salp15 and its specificity for CD4+ T cells.</jats:p>
収録刊行物
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- The Journal of Immunology
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The Journal of Immunology 177 (10), 6579-6583, 2006-11
Oxford University Press (OUP)