Inhibition of human immunodeficiency virus type 1 RNase H by sulfated polyanions

DOI Web Site 被引用文献1件
  • K Moelling
    Max-Planck-Institut für Molekulare Genetik, Berlin, Federal Republic of Germany.
  • T Schulze
    Max-Planck-Institut für Molekulare Genetik, Berlin, Federal Republic of Germany.
  • H Diringer
    Max-Planck-Institut für Molekulare Genetik, Berlin, Federal Republic of Germany.

書誌事項

公開日
1989-12
権利情報
  • https://journals.asm.org/non-commercial-tdm-license
DOI
  • 10.1128/jvi.63.12.5489-5491.1989
公開者
American Society for Microbiology

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説明

<jats:p>The reverse transcriptase (RT) activity of human immunodeficiency virus type 1 and other retroviruses is closely associated with a hybrid-degrading RNase H activity which is essential for retroviral replication. We have analyzed the effect of sulfated polysaccharides on human immunodeficiency virus type 1 recombinant RT and RNase H activities in vitro. Heparin, dextran sulfates, and xylan polysulfate were found to be much more potent inhibitors of RNase H than of RT and exhibit 50% infective doses of 0.04 to 0.1 micrograms/ml (corresponding to 0.1 to 25 nM) which is up to 5,000-fold more efficient than that for RT. Inhibitors of RNase H activity are attractive as antiviral drugs.</jats:p>

収録刊行物

  • Journal of Virology

    Journal of Virology 63 (12), 5489-5491, 1989-12

    American Society for Microbiology

被引用文献 (1)*注記

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