The Cholinergic Neuronal Differentiation Factor from Heart Cells Is Identical to Leukemia Inhibitory Factor
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- Tetsuo Yamamori
- Biology Division, California Institute of Technology, Pasadena, CA 91125.
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- Keiko Fukada
- Biology Division, California Institute of Technology, Pasadena, CA 91125.
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- Ruedi Aebersold
- Biology Division, California Institute of Technology, Pasadena, CA 91125.
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- Sigrun Korsching
- Biology Division, California Institute of Technology, Pasadena, CA 91125.
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- Ming-Ji Fann
- Biology Division, California Institute of Technology, Pasadena, CA 91125.
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- Paul H. Patterson
- Biology Division, California Institute of Technology, Pasadena, CA 91125.
書誌事項
- 公開日
- 1989-12-15
- DOI
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- 10.1126/science.2512641
- 公開者
- American Association for the Advancement of Science (AAAS)
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説明
<jats:p>A protein secreted by cultured rat heart cells can direct the choice of neurotransmitter phenotype made by cultured rat sympathetic neurons. Structural analysis and biological assays demonstrated that this protein is identical to a protein that regulates the growth and differentiation of embryonic stem cells and myeloid cells, and that stimulates bone remodeling and acute-phase protein synthesis in hepatocytes. This protein has been termed D factor, DIA, DIF, DRF, HSFIII, and LIF. Thus, this cytokine, like IL-6 and TGFβ, regulates growth and differentiation in the embryo and in the adult in many tissues, now including the nervous system.</jats:p>
収録刊行物
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- Science
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Science 246 (4936), 1412-1416, 1989-12-15
American Association for the Advancement of Science (AAAS)