The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

DOI Web Site 10 Citations
  • Lakshmanane Premkumar
    Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Bruno Segovia-Chumbez
    Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Ramesh Jadi
    Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • David R. Martinez
    Department of Epidemiology, UNC Chapel Hill School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Rajendra Raut
    Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Alena J. Markmann
    Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Caleb Cornaby
    Immunology/Histocompatibility and Immunogenetics Laboratories, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Luther Bartelt
    Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Susan Weiss
    Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Yara Park
    Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Caitlin E. Edwards
    Department of Epidemiology, UNC Chapel Hill School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Eric Weimer
    Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Erin M. Scherer
    Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Decatur, GA 30322, USA.
  • Nadine Rouphael
    Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Decatur, GA 30322, USA.
  • Srilatha Edupuganti
    Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Decatur, GA 30322, USA.
  • Daniela Weiskopf
    Center for Infectious Disease and Vaccine Research, Institute for Immunology (LJI), La Jolla, La Jolla, CA 92037, USA.
  • Longping V. Tse
    Department of Epidemiology, UNC Chapel Hill School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Yixuan J. Hou
    Department of Epidemiology, UNC Chapel Hill School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • David Margolis
    Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Alessandro Sette
    Center for Infectious Disease and Vaccine Research, Institute for Immunology (LJI), La Jolla, La Jolla, CA 92037, USA.
  • Matthew H. Collins
    Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Decatur, GA 30322, USA.
  • John Schmitz
    Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Ralph S. Baric
    Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Aravinda M. de Silva
    Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

Description

<jats:p>The serum level of RBD-binding antibodies correlates with SARS-CoV-2 neutralization and can be used for population-level surveillance.</jats:p>

Journal

  • Science Immunology

    Science Immunology 5 (48), eabc8413-, 2020-06-26

    American Association for the Advancement of Science (AAAS)

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