Evaluation of Self-Absorbed Doses for the Kidneys of a Voxel Mouse

書誌事項

公開日
2008-06
DOI
  • 10.1080/00223131.2008.10875839
公開者
Informa UK Limited

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説明

Kidney dosimetry in mice is of considerable significance in preclinical studies of new radiopharmaceuticals. There has been a gradual accumulation of kidney dosimetry data in mouse studies. However, a comprehensive understanding of the kidney dosimetry is still lacking. To conduct reliable kidney dosimetry, there exists a need to evaluate self-absorbed fractions (self-AFs) for sophisticated models of the kidneys. In the present study, self-AFs for photons and electrons in the kidneys of a voxel mouse were evaluated using Monte Carlo simulations. The sources were assumed to be monoenergetic in the energy range 10 keV-4 MeV, and be uniformly distributed in the kidneys. The self-AFs for the kidneys of the voxel mouse were compared with those for voxel humans. In addition, self-S values (μGy/MBq·s) for 18F and 90Y of potential interest in the kidney dosimetry were assessed using the self-AFs. It was found that the photon self-AFs for the voxel mouse are significantly smaller than those for the voxel humans an...

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