Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide–quadruplex complex
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- Brahim Heddi
- School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371
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- Vee Vee Cheong
- School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371
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- Herry Martadinata
- School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371
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- Anh Tuân Phan
- School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371
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説明
<jats:title>Significance</jats:title> <jats:p>G-quadruplexes (G4) are four-stranded nucleic acid structures implicated in important biological processes. Interaction between G4 and proteins is essential for the cellular functions of G4. The DEAH (Asp-Glu-Ala-His) box RNA helicase associated with AU-rich element (RHAU) (also named DHX36 or G4R1) specifically binds and unwinds G4 structures. The structure of an 18-aa peptide, identified as the G4-binding domain of RHAU, was solved in the complex with a G4 by NMR spectroscopy. The structure of the complex explains how RHAU specifically recognizes G4 structures and suggests a strategy for G4 recognition by proteins.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 112 (31), 9608-9613, 2015-07-20
Proceedings of the National Academy of Sciences
