Effect of amitriptyline on gastric ulceration

書誌事項

公開日
2002-08
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1046/j.1472-8206.2002.00092.x
公開者
Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>Amitriptyline significantly inhibited alcohol, aspirin, indomethacin and cold‐restraint stress‐induced ulceration. Secretory studies conducted in pyloric‐ligated rats revealed that the drug, at the doses employed, significantly reduced total acidity and protein content. However, significant reductions of the gastric volume were only observed at the highest dose of the drug. In another set of experiments, when 50% alcohol (v/v) was administered to the pyloric‐ligated rats pretreated with amitriptyline, it was observed that the drug significantly reduced the pH, total acidity and protein content.</jats:p>

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