Activation of the Complement System During and After Cardiopulmonary Bypass Surgery

DOI Web Site 被引用文献18件
  • Peter Bruins
    From the Departments of Anaesthesiology (P.B., E.M.F.H. de B., A.T.) and Cardiopulmonary Surgery (A.P.Y., P.G.M.J., F.W.J. van H., C.R.H.W., L.E.), Academic Medical Centre, Amsterdam, and the Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Academic Medical Centre (H. te V., C.E.H.), Amsterdam, the Netherlands.
  • Henk te Velthuis
    From the Departments of Anaesthesiology (P.B., E.M.F.H. de B., A.T.) and Cardiopulmonary Surgery (A.P.Y., P.G.M.J., F.W.J. van H., C.R.H.W., L.E.), Academic Medical Centre, Amsterdam, and the Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Academic Medical Centre (H. te V., C.E.H.), Amsterdam, the Netherlands.
  • Aria P. Yazdanbakhsh
    From the Departments of Anaesthesiology (P.B., E.M.F.H. de B., A.T.) and Cardiopulmonary Surgery (A.P.Y., P.G.M.J., F.W.J. van H., C.R.H.W., L.E.), Academic Medical Centre, Amsterdam, and the Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Academic Medical Centre (H. te V., C.E.H.), Amsterdam, the Netherlands.
  • Piet G. M. Jansen
    From the Departments of Anaesthesiology (P.B., E.M.F.H. de B., A.T.) and Cardiopulmonary Surgery (A.P.Y., P.G.M.J., F.W.J. van H., C.R.H.W., L.E.), Academic Medical Centre, Amsterdam, and the Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Academic Medical Centre (H. te V., C.E.H.), Amsterdam, the Netherlands.
  • Fred W. J. van Hardevelt
    From the Departments of Anaesthesiology (P.B., E.M.F.H. de B., A.T.) and Cardiopulmonary Surgery (A.P.Y., P.G.M.J., F.W.J. van H., C.R.H.W., L.E.), Academic Medical Centre, Amsterdam, and the Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Academic Medical Centre (H. te V., C.E.H.), Amsterdam, the Netherlands.
  • Eddy M. F. H. de Beaumont
    From the Departments of Anaesthesiology (P.B., E.M.F.H. de B., A.T.) and Cardiopulmonary Surgery (A.P.Y., P.G.M.J., F.W.J. van H., C.R.H.W., L.E.), Academic Medical Centre, Amsterdam, and the Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Academic Medical Centre (H. te V., C.E.H.), Amsterdam, the Netherlands.
  • Charles R. H. Wildevuur
    From the Departments of Anaesthesiology (P.B., E.M.F.H. de B., A.T.) and Cardiopulmonary Surgery (A.P.Y., P.G.M.J., F.W.J. van H., C.R.H.W., L.E.), Academic Medical Centre, Amsterdam, and the Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Academic Medical Centre (H. te V., C.E.H.), Amsterdam, the Netherlands.
  • León Eijsman
    From the Departments of Anaesthesiology (P.B., E.M.F.H. de B., A.T.) and Cardiopulmonary Surgery (A.P.Y., P.G.M.J., F.W.J. van H., C.R.H.W., L.E.), Academic Medical Centre, Amsterdam, and the Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Academic Medical Centre (H. te V., C.E.H.), Amsterdam, the Netherlands.
  • Ad Trouwborst
    From the Departments of Anaesthesiology (P.B., E.M.F.H. de B., A.T.) and Cardiopulmonary Surgery (A.P.Y., P.G.M.J., F.W.J. van H., C.R.H.W., L.E.), Academic Medical Centre, Amsterdam, and the Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Academic Medical Centre (H. te V., C.E.H.), Amsterdam, the Netherlands.
  • C. Erik Hack
    From the Departments of Anaesthesiology (P.B., E.M.F.H. de B., A.T.) and Cardiopulmonary Surgery (A.P.Y., P.G.M.J., F.W.J. van H., C.R.H.W., L.E.), Academic Medical Centre, Amsterdam, and the Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Academic Medical Centre (H. te V., C.E.H.), Amsterdam, the Netherlands.

書誌事項

タイトル別名
  • Postsurgery Activation Involves C-Reactive Protein and Is Associated With Postoperative Arrhythmia
公開日
1997-11-18
DOI
  • 10.1161/01.cir.96.10.3542
公開者
Ovid Technologies (Wolters Kluwer Health)

この論文をさがす

説明

<jats:p> <jats:italic>Background</jats:italic> Complement activation during cardiopulmonary bypass (CPB) surgery is considered to result from interaction of blood with the extracorporeal circuit. We investigated whether additional mechanisms may contribute to complement activation during and after CPB and, in particular, focused on a possible role of the acute-phase protein C–reactive protein (CRP). </jats:p> <jats:p> <jats:italic>Methods and Results</jats:italic> In 19 patients enrolled for myocardial revascularization, perioperative and postoperative levels of complement activation products, interleukin-6 (IL-6), CRP, and complement-CRP complexes, reflecting CRP-mediated complement activation in vivo, were measured and related to clinical symptoms. A biphasic activation of complement was observed. The ratio between the areas under the curve of perioperative and postoperative C3b/c and C4b/c were 3:2 and 1:46, respectively. IL-6 levels reached a maximum at 6 hours post-surgery. CRP levels peaked on the second postoperative day. Each complement-CRP complex had peak levels on the second or third postoperative day. By multivariate analysis, maximum levels of CRP on the second postoperative day were mainly explained by C4b/c levels after protamine administration, leukocyte count on the second postoperative day, and preoperative levels of CRP. Peak levels of C4b/c after protamine administration ( <jats:italic>P</jats:italic> =.0073) and on the second postoperative day correlated with the occurrence of arrhythmia on the same day ( <jats:italic>P</jats:italic> =.0065). </jats:p> <jats:p> <jats:italic>Conclusions</jats:italic> Cardiac surgery with CPB causes a biphasic complement activation. The first phase occurs during CPB and results from the interaction of blood with the extracorporeal circuit. The second phase, which occurs during the first 5 days after surgery, involves CRP, is related to baseline CRP levels, and is associated with clinical symptoms such as arrhythmia. </jats:p>

収録刊行物

  • Circulation

    Circulation 96 (10), 3542-3548, 1997-11-18

    Ovid Technologies (Wolters Kluwer Health)

被引用文献 (18)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ