Dietary oligofructose lowers triglycerides, phospholipids and cholesterol in serum and very low density lipoproteins of rats
-
- Maria Fiordaliso
- Unité de Biochimie Toxicologique et Cancérologique, Département des Sciences Pharmaceutiques Université Catholique de Louvain 7369 Avenue Mounier, 73 Brussels B‐1200 Belgium
-
- Nadine Kok
- Unité de Biochimie Toxicologique et Cancérologique, Département des Sciences Pharmaceutiques Université Catholique de Louvain 7369 Avenue Mounier, 73 Brussels B‐1200 Belgium
-
- Jean‐Pierre Desager
- Laboratoire de Pharmacothérapie, Faculté de Médecine Université Catholique de Louvain Brussels B‐1200 Belgium
-
- Fabienne Goethals
- Unité de Biochimie Toxicologique et Cancérologique, Département des Sciences Pharmaceutiques Université Catholique de Louvain 7369 Avenue Mounier, 73 Brussels B‐1200 Belgium
-
- Dominique Deboyser
- Unité de Biochimie Toxicologique et Cancérologique, Département des Sciences Pharmaceutiques Université Catholique de Louvain 7369 Avenue Mounier, 73 Brussels B‐1200 Belgium
-
- Marcel Roberfroid
- Unité de Biochimie Toxicologique et Cancérologique, Département des Sciences Pharmaceutiques Université Catholique de Louvain 7369 Avenue Mounier, 73 Brussels B‐1200 Belgium
-
- Nathalie Delzenne
- Unité de Biochimie Toxicologique et Cancérologique, Département des Sciences Pharmaceutiques Université Catholique de Louvain 7369 Avenue Mounier, 73 Brussels B‐1200 Belgium
書誌事項
- 公開日
- 1995-02
- 権利情報
-
- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
-
- 10.1007/bf02538270
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>The present study was aimed at answering the question why feeding rats an oligofructose (OFS) supplemented diet could cause a significant reduction in plasma lipid levels. Daily administration of a 10% (w/w) OFS‐containing diet to normolipidemic male rats resulted in a decrease in plasma triglycerides, phospholipids and cholesterol. The triglyceride‐lowering effect was observed after one week and lasted for at least 16 wk and was associated with a reduction in plasma very low density lipoproteins, indicating that the hypolipidemic effect of OFS may be due to changes in liver lipid metabolism. We therefore tested whether OFS feeding modified the capacity of the liver to synthesize triglycerides from free fatty acids. Hepatocytes isolated from livers of control and OFS‐fed rats were incubated in the presence of [1‐<jats:sup>14</jats:sup>C]palmitate, and both intracellular and extracellular [<jats:sup>14</jats:sup>C]triglyceride formation were quantified. We found that chronic feeding of an OFS‐supplemented diet to rats significantly reduced the capacity of isolated hepatocytes to synthesize triglycerides from palmitate. The results suggest that, like other soluble dietary fibers, OFS significantly alters liver lipid metabolism, resulting over time in a significant reduction in plasma triglyceride, phospholipid and cholesterol levels.</jats:p>
収録刊行物
-
- Lipids
-
Lipids 30 (2), 163-167, 1995-02
Wiley
