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- C.D. van der Maarel-Wierink
- BENECOMO, Flemish-Netherlands Geriatric Oral Research Group
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- J.N.O. Vanobbergen
- BENECOMO, Flemish-Netherlands Geriatric Oral Research Group
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- E.M. Bronkhorst
- Department of Preventive and Restorative Dentistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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- J.M.G.A. Schols
- BENECOMO, Flemish-Netherlands Geriatric Oral Research Group
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- C. de Baat
- BENECOMO, Flemish-Netherlands Geriatric Oral Research Group
説明
<jats:p>As part of a systematic literature review, a comprehensive literature search was carried out to identify risk factors for aspiration pneumonia in frail older people. A prominent risk factor found was dysphagia with evidence level 2a, according to the Oxford Centre for Evidence-based Medicine Levels of Evidence. Subsequently, a meta-analysis of 4 cohort, 1 case-cohort, and 1 case-control study on dysphagia as a risk factor of aspiration pneumonia in frail older people was performed. Using a random effects model, we found a positive correlation between dysphagia and aspiration pneumonia: OR = 9.84; 95%CI = 4.15 - 23.33 (test for statistical homogeneity: p < 0.001). Then, a subgroup meta-analysis was performed with 4 cohort studies, all including patients with a cerebrovascular disease. Once again, a positive correlation was found between dysphagia and aspiration pneumonia: OR = 12.93; 95%CI = 8.61 - 19.44. The test for statistical homogeneity revealed no statistically significant result (p = 0.15). It was concluded that dysphagia is a serious risk factor for aspiration pneumonia in frail older people, particularly in those suffering from a cerebrovascular disease.</jats:p>
収録刊行物
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- Journal of Dental Research
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Journal of Dental Research 90 (12), 1398-1404, 2011-09-22
SAGE Publications